Department of Neurosurgery, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK.
J Neurooncol. 2010 Feb;96(3):385-92. doi: 10.1007/s11060-009-9970-9. Epub 2009 Jul 19.
Apparent diffusion coefficient (ADC) describes water diffusion within tissues. Previous studies report a negative linear correlation between minimum ADC and tumour cellularity in different types of gliomas, but there are no studies in oligodendroglial tumours. This study evaluated the relationship between ADC and tumour cellularity in oligodendroglial tumours characterized by genotype.
ADC was assessed in 17 patients with known 1p/19q status: 3 grade II oligodendrogliomas (OII), 9 grade II oligoastrocytomas (OAII), 5 grade III oligoastrocytomas (OAIII). Regions of interest were placed on ADC maps around tumour margins to generate mean tumour ADC, and over minimum and maximum tumour ADC. Histopathology assessment of tumour cellularity determined minimum, maximum and mean cell density in serial stereotactic biopsies.
1p/19q loss was present in 2/3 OII, 5/9 OAII, 2/5 OAIII. Grade III tumours had higher maximum cell density than grade II tumours (17.2 vs. 10.57%: Mann Whitney U; P = 0.20). Oligoastrocytoma were more likely to have a lower minimum cell density than oligodendrogliomas (Mann Whitney U; P = 0.032). There was no relationship between cell density and genotype. There was no linear correlation between mean ADC and mean cell density (Spearman's rho; r = 0.486: P = 0.438), minimum ADC and maximum cell density (Spearman's rho; r = 0.158: P = 0.660), and maximum ADC and minimum cell density (Spearman's rho; r = 0.039: P = 0.985).
In oligodendroglial tumours there is no relationship between quantitative assessment of cellularity and ADC. This may reflect differences in oligodendroglial tumour biology compared to other gliomas, although the composition of the extracellular matrix may influence ADC more than cellularity.
表观扩散系数（ADC）描述了组织内的水分子扩散。先前的研究报告称，不同类型的胶质瘤中，最小 ADC 与肿瘤细胞密度呈负线性相关，但少突胶质细胞瘤中尚无此类研究。本研究评估了基因型特征的少突胶质细胞瘤中 ADC 与肿瘤细胞密度之间的关系。
对 17 名已知 1p/19q 状态的患者进行 ADC 评估：3 级少突胶质细胞瘤（OII），9 级少突星形细胞瘤（OAII），5 级少突星形细胞瘤（OAIII）。在肿瘤边缘的 ADC 图上放置感兴趣区，以生成平均肿瘤 ADC、最小和最大肿瘤 ADC。通过对立体定向活检的连续切片进行组织病理学评估，确定最小、最大和平均细胞密度。
2/3 的 OII、5/9 的 OAII、2/5 的 OAIII 存在 1p/19q 缺失。III 级肿瘤的最大细胞密度高于 II 级肿瘤（17.2%与 10.57%：Mann-Whitney U；P=0.20）。少突星形细胞瘤的最小细胞密度比少突胶质细胞瘤更可能降低（Mann-Whitney U；P=0.032）。细胞密度与基因型之间无相关性。平均 ADC 与平均细胞密度之间无线性相关性（Spearman's rho；r=0.486：P=0.438），最小 ADC 与最大细胞密度（Spearman's rho；r=0.158：P=0.660），最大 ADC 与最小细胞密度（Spearman's rho；r=0.039：P=0.985）。
在少突胶质细胞瘤中，细胞密度的定量评估与 ADC 之间无相关性。这可能反映了少突胶质细胞瘤生物学与其他胶质瘤的差异，尽管细胞外基质的组成可能比细胞密度对 ADC 的影响更大。
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