Villatoro-Hernandez Julio, Arce-Mendoza Alma Yolanda, Rosas-Taraco Adrian G, Esparza-González Sandra Cecilia, Guzmán-López Santos, Elizondo-Omaña Rodrigo E, Chávez-Reyes Arturo, Saucedo-Cárdenas Odila, de Oca Luna Roberto Montes
Departamento de Histología, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño s/n, 64460, Monterrey, NL, Mexico.
Biotechnol Lett. 2009 Nov;31(11):1795-800. doi: 10.1007/s10529-009-0081-7. Epub 2009 Jul 18.
Chemokines are members of the super family of cytokines necessary for leukocyte recruitment in tissues and lymphoid organs. The interferon-gamma inducible protein-10 (IP-10) chemo-attracts CXCR3-expressing cells, such as activated T lymphocytes and monocytes. We have genetically engineered a strain of Lactococcus lactis to secrete a biologically active murine IP-10 that interacts with human CXCR3, its homolog receptor, and chemo-attracts human CD3+ T lymphocytes.
