MTG基因在发育中的小鼠中枢神经系统中的区域表达。
Regional expression of MTG genes in the developing mouse central nervous system.
作者信息
Alishahi Amin, Koyano-Nakagawa Naoko, Nakagawa Yasushi
机构信息
Department of Neuroscience and Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
出版信息
Dev Dyn. 2009 Aug;238(8):2095-102. doi: 10.1002/dvdy.22021.
Myeloid translocation gene (MTG) proteins are transcriptional repressors that are highly conserved across species. We studied the expression of three members of this gene family, MTGR1, MTG8, and MTG16 in developing mouse central nervous system by in situ hybridization. All of these genes are detected as early as embryonic day 11.5. Because these genes are known to be induced by proneural genes during neurogenesis, we analyzed the expression of MTG genes in relation to two proneural genes, Neurog2 (also known as Ngn2 or Neurogenin 2) and Ascl1 (also known as Mash1). While MTGR1 are generally expressed in regions that also express Neurog2, MTG8 and MTG16 expression is associated more tightly with that of Ascl1-expressing neural progenitor cells. These results suggest the possibility that expression of MTG genes is differentially controlled by specific proneural genes during neurogenesis.
髓系易位基因（MTG）蛋白是转录抑制因子，在物种间高度保守。我们通过原位杂交研究了该基因家族的三个成员MTGR1、MTG8和MTG16在发育中的小鼠中枢神经系统中的表达。早在胚胎第11.5天就检测到了所有这些基因。由于已知这些基因在神经发生过程中由神经前体基因诱导，我们分析了MTG基因与两个神经前体基因Neurog2（也称为Ngn2或神经生成素2）和Ascl1（也称为Mash1）相关的表达。虽然MTGR1通常在也表达Neurog2的区域表达，但MTG8和MTG16的表达与表达Ascl1的神经祖细胞的表达联系更为紧密。这些结果提示了在神经发生过程中MTG基因的表达可能受特定神经前体基因差异调控的可能性。
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