Goraksha-Hicks Pankuri, Rathmell Jeffrey C
Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Dev Cell. 2009 Jul;17(1):6-8. doi: 10.1016/j.devcel.2009.07.004.
Nutrient overabundance is known to promote cellular hypertrophy, a significant pathological event in diseases like diabetes and cancer, although mechanisms have remained unclear. In this issue of Developmental Cell, Wu and Derynck provide a new model that links metabolism and cell growth by demonstrating that hyperglycemia can increase TGF-beta-dependent activation of the mTOR pathway to promote cellular hyperplasia.
营养物质过剩已知会促进细胞肥大，这是糖尿病和癌症等疾病中的一个重要病理事件，尽管其机制尚不清楚。在本期《发育细胞》中，吴和德赖恩克提出了一个新模型，该模型通过证明高血糖可增加TGF-β依赖的mTOR途径激活以促进细胞增生，从而将代谢与细胞生长联系起来。
