糖尿病发病时的心电图变化及有氧运动训练对 Zucker 糖尿病肥胖（ZDF）大鼠的影响。

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat.

机构信息

Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, MS 2002, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

出版信息

Cardiovasc Diabetol. 2010 Sep 22;9:56. doi: 10.1186/1475-2840-9-56.

DOI:10.1186/1475-2840-9-56

PMID:20860788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2954909/

Abstract

BACKGROUND

Early markers of diabetic autonomic neuropathy (DAN) in an electrocardiogram (ECG) include elevated R wave amplitudes, widening of QTc intervals and decreased heart rate variability (HRV). The severity of DAN has a direct relationship with mortality risk. Aerobic exercise training is a common recommendation for the delay and possible reversal of cardiac dysfunction. Limited research exists on ECG measures for the evaluation of aerobic exercise training in Zucker Diabetic Fatty (ZDF) rat, a model of type 2 diabetes. The objective of this study was to assess whether aerobic exercise training may attenuate diabetes induced ECG changes.

METHODS

Male ZDF (obese fa/fa) and control Zucker (lean fa/+) rats were assigned to 4 groups: sedentary control (SC), sedentary diabetic (SD), exercised control (EC) and exercised diabetic (ED). The exercised groups began 7 weeks of treadmill training after the development of diabetes in the ED group. Baseline (prior to the training) and termination measurements included body weight, heart weight, blood glucose and glycated hemoglobin levels and ECG parameters. One way repeated measures ANOVA (group) analyzed within and between subject differences and interactions. Pearson coefficients and descriptive statistics described variable relationships and animal characteristics.

RESULTS

Diabetes caused crucial changes in R wave amplitudes (p < 0.001), heart rate variability (p < 0.01), QT intervals (p < 0.001) and QTc intervals (p < 0.001). R wave amplitude augmentation in SD rats from baseline to termination was ameliorated by exercise, resulting in R wave amplitude changes in ED animals similar to control rats. Aerobic exercise training neither attenuated QT or QTc interval prolongation nor restored decreases in HRV in diabetic rats.

CONCLUSION

This study revealed alterations in R wave amplitudes, HRV, QT and QTc intervals in ZDF rats. Of these changes, aerobic exercise training was able to correct R wave amplitude changes. In addition, exercise has beneficial effect in this diabetic rat model in regards to ECG correlates of left ventricular mass.

摘要

背景

心电图（ECG）中糖尿病自主神经病变（DAN）的早期标志物包括 R 波振幅升高、QTc 间期增宽和心率变异性（HRV）降低。DAN 的严重程度与死亡率风险直接相关。有氧运动训练是延迟和可能逆转心脏功能障碍的常见建议。关于有氧运动训练对 2 型糖尿病模型 Zucker 糖尿病肥胖（ZDF）大鼠心电图评估的研究有限。本研究旨在评估有氧运动训练是否可能减轻糖尿病引起的心电图变化。

方法

雄性 ZDF（肥胖 fa/fa）和对照 Zucker（瘦 fa/+）大鼠被分为 4 组：安静对照（SC）、安静糖尿病（SD）、运动对照（EC）和运动糖尿病（ED）。ED 组糖尿病发生后，运动组开始进行 7 周的跑步机训练。基线（训练前）和终止测量包括体重、心脏重量、血糖和糖化血红蛋白水平以及心电图参数。单向重复测量方差分析（组）分析了组内和组间差异以及相互作用。Pearson 系数和描述性统计描述了变量关系和动物特征。

结果

糖尿病导致 R 波振幅（p < 0.001）、心率变异性（p < 0.01）、QT 间期（p < 0.001）和 QTc 间期（p < 0.001）发生关键变化。SD 大鼠从基线到终止的 R 波振幅增加被运动改善，导致 ED 动物的 R 波振幅变化与对照大鼠相似。有氧运动训练既不能减轻糖尿病大鼠 QT 或 QTc 间期延长，也不能恢复 HRV 降低。