通过不同的秀丽隐杆线虫Wnt信号通路视角重新审视TCF和β-连环蛋白。
A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway.
作者信息
Phillips Bryan T, Kimble Judith
机构信息
Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.
出版信息
Dev Cell. 2009 Jul;17(1):27-34. doi: 10.1016/j.devcel.2009.07.002.
Abstract
The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual features may have important implications for the canonical Wnt/beta-catenin pathway.
摘要
经典的Wnt/β-连环蛋白信号通路已得到广泛研究，具有广泛的保守性且在临床上具有重要意义。在本综述中，我们描述了秀丽隐杆线虫的Wnt/β-连环蛋白不对称信号通路，并指出其一些独特特征可能对经典的Wnt/β-连环蛋白信号通路具有重要意义。
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