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人博卡病毒:儿童严重哮喘加重的一个病因

Human bocavirus: a cause of severe asthma exacerbation in children.

作者信息

Vallet Christelle, Pons-Catalano Charlotte, Mandelcwajg Alexis, Wang Andrew, Raymond Josette, Lebon Pierre, Gendrel Dominique

机构信息

Pediatric Unit, Paris Descartes University and AP-HP Saint Vincent de Paul-Cochin Hospital, Paris, France.

出版信息

J Pediatr. 2009 Aug;155(2):286-8. doi: 10.1016/j.jpeds.2009.01.069.

DOI:10.1016/j.jpeds.2009.01.069
PMID:19619752
Abstract

Real-time polymerase chain reaction for human bocavirus (HBoV) was performed in nasopharyngeal aspirate specimens from 166 children over 2 years of age hospitalized for severe asthma exacerbation. Whereas HBoV was detected in 21 of these children (13%), it was found in only 1 of 50 ambulatory children with stable asthma (2%), suggesting a major role of HBoV in acute exacerbations in asthmatic children.

摘要

对166名因重度哮喘急性发作而住院的2岁以上儿童的鼻咽抽吸物样本进行了人博卡病毒(HBoV)的实时聚合酶链反应检测。在这些儿童中,有21名(13%)检测到HBoV,而在50名哮喘病情稳定的门诊儿童中,只有1名(2%)检测到该病毒,这表明HBoV在哮喘儿童急性发作中起主要作用。

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The effects of human parvovirus VP1 unique region in a mouse model of allergic asthma.人类细小病毒 VP1 独特区域在过敏性哮喘小鼠模型中的作用。
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Small Animal Models of Respiratory Viral Infection Related to Asthma.
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Investigation of markers of allergic sensitization and viral infections in children with allergy and asthma.对过敏和哮喘儿童的过敏致敏及病毒感染标志物的研究。
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The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma.病毒感染在慢性阻塞性肺疾病和哮喘急性加重中的作用。
Ther Adv Respir Dis. 2016 Apr;10(2):158-74. doi: 10.1177/1753465815618113. Epub 2015 Nov 26.
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