Ouyang Ming-Wen, Lin Chun-Shui, Qin Zai-Sheng, Gu Miao-Ning
Department of Anesthesiology, Nanfang Hospital, Southern University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jul;29(7):1471-3.
To investigate the changes of EEG approximate entropy (ApEn) in rats during focal cerebral infarction.
Twenty-four Sprague-Dawley (SD) rats were randomly divided into infarction group (n=12) with middle cerebral artery occlusion and sham-operated group (n=12). The EEG data (ApEn) was recorded in the bilateral areas (C3, C4) of the rats with focal cerebral infarction before the infarction and immediately and at 5, 15, 30, and 60 min after the infarction. The same measurement was carried out in the sham-operated group.
In the sham-operated group, ApEn in C3 and C4 showed no obvious differences at the time points (P>0.05), but in the infarction group, ApEn in C3 and C4 increased significantly after the infarction. ApEn in the ischemic area (C4) was significantly lower than that in the non-ischemic area (C3) (P<0.05). The bilateral ApEn decreased with the passage of time. ApEn in the ischemic area (C4) was significantly lowered at 30 min after the infarction in comparison with that before infarction (P<0.05). In the sham-operated group, ApEn showed no significant difference between C3 and C4. ApEn was comparable between the two groups before the operation.
ApEn can help monitor the occurrence of focal cerebral infarction of rats, and may be used to assess the extent of cerebral ischemia after infarction.
探讨局灶性脑梗死大鼠脑电图近似熵（ApEn）的变化。
将24只Sprague-Dawley（SD）大鼠随机分为大脑中动脉闭塞梗死组（n = 12）和假手术组（n = 12）。记录局灶性脑梗死大鼠梗死前、梗死即刻以及梗死后5、15、30和60分钟双侧（C3、C4）区域的脑电图数据（近似熵）。假手术组大鼠进行相同测量。
假手术组C3和C4区域的ApEn在各时间点变化不明显（P>0.05），但梗死组在梗死后C3和C4区域的ApEn显著增加。缺血区域（C4）的ApEn明显低于非缺血区域（C3）（P<0.05）。双侧ApEn随时间推移而下降。梗死30分钟时，缺血区域（C4）的ApEn与梗死前相比显著降低（P<0.05）。假手术组C3和C4区域的ApEn无显著差异。两组术前ApEn具有可比性。
近似熵有助于监测大鼠局灶性脑梗死的发生，可能用来评估梗死后脑缺血的程度。
