Turkbey Baris, Kobayashi Hisataka, Ogawa Mikako, Bernardo Marcelino, Choyke Peter L
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr., MSC 1182, Bldg. 10, Rm. 1B40, Bethesda, MD 20892-1088, USA.
AJR Am J Roentgenol. 2009 Aug;193(2):304-13. doi: 10.2214/AJR.09.2869.
Angiogenesis--the growth of new vessels--is both a normal physiologic response and a critical step in many pathologic processes, particularly cancer. Imaging has long relied on the different enhancement characteristics of cancer compared with normal tissue; the information generated is often primarily morphologic and qualitative. However, more quantitative methods based on functional and targeted imaging have recently emerged.
In this article, we review both functional and targeted imaging techniques for assessing tumor angiogenesis.
血管生成——新血管的生长——既是一种正常的生理反应,也是许多病理过程(尤其是癌症)中的关键步骤。长期以来,成像一直依赖于癌症与正常组织相比的不同增强特征;所产生的信息通常主要是形态学和定性的。然而,最近基于功能和靶向成像的更定量的方法已经出现。
在本文中,我们回顾了用于评估肿瘤血管生成的功能和靶向成像技术。