Kaur Geetika, Roy Bipradas
Integrative Biosciences Center, Wayne State University, Detroit, MI 48202, USA.
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Biomedicines. 2024 Apr 9;12(4):827. doi: 10.3390/biomedicines12040827.
Tumor angiogenesis, the formation of new blood vessels within the tumor microenvironment, is considered a hallmark of cancer progression and represents a crucial target for therapeutic intervention. The tumor microenvironment is characterized by a complex interplay between proangiogenic and antiangiogenic factors, regulating the vascularization necessary for tumor growth and metastasis. The study of angiogenesis involves a spectrum of techniques, spanning from biomarker assessment to advanced imaging modalities. This comprehensive review aims to provide insights into the molecular intricacies, regulatory dynamics, and clinical implications of tumor angiogenesis. By delving into these aspects, we gain a deeper understanding of the processes driving vascularization in tumors, paving the way for the development of novel and effective antiangiogenic therapies in the fight against cancer.
肿瘤血管生成是指在肿瘤微环境中形成新的血管，被认为是癌症进展的一个标志，也是治疗干预的关键靶点。肿瘤微环境的特征是促血管生成因子和抗血管生成因子之间复杂的相互作用，这种相互作用调节着肿瘤生长和转移所必需的血管形成。血管生成的研究涉及一系列技术，从生物标志物评估到先进的成像方式。这篇综述旨在深入探讨肿瘤血管生成的分子复杂性、调控动态以及临床意义。通过深入研究这些方面，我们对肿瘤血管形成的驱动过程有了更深入的理解，为开发新型有效的抗血管生成疗法以对抗癌症铺平了道路。
