Weenig Roger H, Comfere Nneka I, Gibson Lawrence E, Alonso-Llamazares Javier, Davis Mark D P, Pittelkow Mark R, el-Azhary Rokea A
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Arch Dermatol. 2009 Jul;145(7):801-8. doi: 10.1001/archdermatol.2009.119.
Psoriasis is a common, nonulcerative skin disorder.
We describe 3 men recently referred to our institution for evaluation and treatment of severe, ulcerative psoriasis that ultimately was determined to be aggressive, cytotoxic, cutaneous lymphoma. Each had a history of relatively indolent, nonulcerative patches and plaques (duration, 2-45 years) that changed to ulcerated lesions; these rapidly progressed and eventuated in death.
The clinical characteristics of the skin lesions and the histopathologic findings form a distinct and rare presentation of cutaneous lymphoma. The initial course is similar to that of mycosis fungoides but eventuates in a highly aggressive disease with fatal outcome.
银屑病是一种常见的非溃疡性皮肤病。
我们描述了3名男性患者，他们近期因严重溃疡性银屑病被转诊至我院评估和治疗，最终确诊为侵袭性细胞毒性皮肤淋巴瘤。他们每个人都有相对惰性的非溃疡性斑块病史（病程2 - 45年），这些斑块后来转变为溃疡性病变；病情迅速进展并最终导致死亡。
皮肤病变的临床特征和组织病理学表现构成了一种独特且罕见的皮肤淋巴瘤表现形式。其初始病程与蕈样肉芽肿相似，但最终会发展为一种具有致命结局的高度侵袭性疾病。
