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需要声门上成形术的重度喉软化症婴儿的同步气道病变及预后

Synchronous airway lesions and outcomes in infants with severe laryngomalacia requiring supraglottoplasty.

作者信息

Schroeder James W, Bhandarkar Naveen D, Holinger Lauren D

机构信息

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.

出版信息

Arch Otolaryngol Head Neck Surg. 2009 Jul;135(7):647-51. doi: 10.1001/archoto.2009.73.

Abstract

OBJECTIVE

To quantify the prevalence and the impact of synchronous airway lesions identified by endoscopy in infants undergoing supraglottoplasty for severe laryngomalacia (LM).

DESIGN

Retrospective study.

SETTING

Tertiary care pediatric hospital.

PATIENTS

Sixty patients who underwent supraglottoplasty for severe LM from 2002 to 2006. Patients who underwent preoperative tracheotomy, had previous airway surgery, or did not have 6 months of follow-up were excluded. Fifty-two patients met inclusion criteria.

INTERVENTION

Supraglottoplasty (with carbon dioxide laser).

MAIN OUTCOME MEASURES

Presence of synchronous airway lesions and their contribution to upper airway obstruction (UAO) and their effect on the postoperative course after supraglottoplasty.

RESULTS

Fifty-eight percent of patients had synchronous airway lesions (SALs), of whom 77% had subglottic stenosis (SGS) and 47% had tracheomalacia, bronchomalacia, or both. Sixty-three percent of all patients required postoperative nonsurgical airway support. Eight patients had residual UAO requiring additional surgical intervention, with 3 revision supraglottoplasties and 7 tracheotomies performed. Infants with neurological conditions had a high rate of surgical intervention (55%; P = .001). Patients with SGS exceeding 35% but without any neurological condition had a prolonged hospital stay (>3.6 days; P = .02) and an 83% incidence (P = .04) of postoperative UAO requiring intubation. Infants with LM with laryngeal edema (LE) alone had increased frequency of postoperative nonsurgical airway support (P = .02) and a prolonged hospital stay of 1 day (P = .01) compared with infants without edema.

CONCLUSIONS

There is a high incidence of SALs in patients undergoing supraglottoplasty. Neurological conditions, hypoplastic mandible, SGS greater than 35%, and preexisting LE independently adversely affected the postoperative course.

摘要

目的

量化在接受声门上成形术治疗重度喉软化症(LM)的婴儿中,经内镜检查发现的同步气道病变的患病率及其影响。

设计

回顾性研究。

地点

三级儿科专科医院。

患者

2002年至2006年期间接受声门上成形术治疗重度LM的60例患者。排除术前接受气管切开术、曾接受气道手术或未进行6个月随访的患者。52例患者符合纳入标准。

干预措施

声门上成形术(使用二氧化碳激光)。

主要观察指标

同步气道病变的存在情况及其对上气道梗阻(UAO)的影响,以及对声门上成形术后病程的影响。

结果

58%的患者存在同步气道病变(SALs),其中77%有声门下狭窄(SGS),47%有气管软化、支气管软化或两者皆有。所有患者中有63%术后需要非手术气道支持。8例患者有残余UAO需要额外的手术干预,进行了3次声门上成形术翻修和7次气管切开术。患有神经系统疾病的婴儿手术干预率较高(55%;P = 0.001)。SGS超过35%但无任何神经系统疾病的患者住院时间延长(>3.6天;P = 0.02),术后UAO需要插管的发生率为83%(P = 0.04)。与无水肿的婴儿相比,仅患有喉水肿(LE)的LM婴儿术后非手术气道支持的频率增加(P = 0.02),住院时间延长1天(P = 0.01)。

结论

接受声门上成形术的患者中SALs的发生率很高。神经系统疾病、下颌骨发育不全、SGS大于35%以及既往存在的LE独立地对术后病程产生不利影响。

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