肺炎球菌蛋白对内耳的毒力。
Virulence of pneumococcal proteins on the inner ear.
作者信息
Schachern Patricia A, Tsuprun Vladimir, Cureoglu Sebahattin, Ferrieri Patricia, Briles David E, Paparella Michael M, Juhn Steven
机构信息
Department of Otolaryngology, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Arch Otolaryngol Head Neck Surg. 2009 Jul;135(7):657-61. doi: 10.1001/archoto.2009.72.
OBJECTIVE
To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear.
MAIN OUTCOME MEASURES
A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear.
RESULTS
Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal.
CONCLUSIONS
Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.
目的
研究特定肺炎球菌蛋白的毒力特性对内耳的影响。
主要观察指标
圆窗膜和内耳炎症细胞浸润及病理变化的组织学比较。
结果
接种高剂量肺炎溶血素或野生型细菌的大多数动物内耳出现严重病理变化。接种表面蛋白A或表面抗原A缺陷型细菌的大多数动物内耳外观正常。
结论
肺炎球菌表面蛋白A和肺炎球菌表面抗原A是肺炎球菌性中耳炎继发内耳损伤的两个重要毒力因子。这些毒力因子的突变导致内耳损伤减轻。
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