Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
Curr Opin Organ Transplant. 2009 Oct;14(5):577-82. doi: 10.1097/MOT.0b013e32833037e8.
As the knowledge of CD4+CD25bright+FoxP3+ regulatory T cells in experimental transplant models grows, we need to understand how and to what extent these suppressor cells regulate donor-directed immune events in the transplantation clinic. This review focuses on the function of regulatory T cells in the peripheral blood and the transplanted organ of patients after heart transplantation during immunological quiescence and rejection.
Here, we present data that peripheral CD4+CD25bright+FoxP3+ T cells of heart transplant patients who experience acute rejection have inadequate immune regulatory function in vitro compared with those of nonrejecting patients. During rejection, potent donor-specific T-cell suppressors are present in the transplanted organ.
The studies in transplant patients' show that the function of CD4+CD25bright+FoxP3+ regulatory T cells in alloimmunity is to inhibit the activation of effector T cells, to prevent rejection, and to control the antidonor response at the graft itself at later stages of immune reactivity.
随着人们对实验性移植模型中 CD4+CD25bright+FoxP3+调节性 T 细胞的认识不断深入，我们需要了解这些抑制性细胞在移植临床中是如何以及在何种程度上调节供体定向免疫事件。本综述重点介绍了在免疫静止和排斥期间，心脏移植患者外周血和移植器官中调节性 T 细胞的功能。
这里，我们提供的数据表明，经历急性排斥反应的心脏移植患者外周血 CD4+CD25bright+FoxP3+T 细胞的体外免疫调节功能与非排斥患者相比明显不足。在排斥期间，移植器官中存在有效的供体特异性 T 细胞抑制物。
在移植患者中的研究表明，CD4+CD25bright+FoxP3+调节性 T 细胞在同种异体免疫中的功能是抑制效应 T 细胞的激活，防止排斥反应，并在免疫反应的后期控制移植物本身的抗供体反应。
