手术诱导的胆管损伤后会出现早期肝脏氧化应激。一项在大鼠身上的初步实验研究。

Surgically-induced bile duct injury is followed by early hepatic oxidative stress. A preliminary experimental study in rats.

作者信息

Lissidini Germana, Piccinni Giuseppe, Portincasa Piero, Grattagliano Ignazio, Gurrado Angela, Testini Mario

机构信息

Section of General Surgery A. De Blasi Department for the Application in Surgery of Innovative Technologies, University of Bari, Bari, Italy.

出版信息

Hepatogastroenterology. 2009 May-Jun;56(91-92):602-5.

PMID:19621663

Abstract

BACKGROUND/AIMS: To study in the rat whether oxidative stress appears early in a model of short-term cholestasis induced by bile duct ligation.

METHODOLOGY

Adult male rats underwent proximal bile duct ligation; controls underwent a sham operation. Animals were sacrificed at days 0, 1, 3, 7 and 10. Livers were removed for histological studies and biochemical analysis.

RESULTS

GSH and PSH levels declined earlier in mitochondria than cytosol. Data were analyzed for statistical significance by ANOVA analysis.

CONCLUSIONS

This study represents an experimental model which helps in the interpretation of the damage induced by bile duct injury in humans emphasizing an early detection of bile duct injury after surgery to ensure appropriate treatment and optimal patient outcome.

摘要

背景/目的：在大鼠中研究在胆管结扎诱导的短期胆汁淤积模型中氧化应激是否早期出现。