Chang Jungsoo, Yu Beverly, Saltzman W Mark, Girardi Michael
Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
Biomedical Engineering, Yale School of Engineering & Applied Science, New Haven, Connecticut, USA.
JID Innov. 2023 Mar 16;3(4):100197. doi: 10.1016/j.xjidi.2023.100197. eCollection 2023 Jul.
The use of nanoparticles (NPs) as a therapeutic delivery system has expanded markedly over the past decade, particularly regarding applications targeting the skin. The delivery of NP-based therapeutics to the skin requires special consideration owing to its role as both a physical and immunologic barrier, and specific technologies must not only take into consideration the target but also the pathway of delivery. The unique challenge this poses has been met with the development of a wide panel of NP-based technologies meant to precisely address these considerations. In this review article, we describe the application of NP-based technologies for drug delivery targeting the skin, summarize the types of NPs, and discuss the current landscape of NPs for skin cancer prevention and skin cancer treatment as well as future directions within these applications.
在过去十年中，纳米颗粒（NPs）作为一种治疗性递送系统的应用显著扩展，尤其是在针对皮肤的应用方面。由于皮肤兼具物理和免疫屏障的作用，将基于纳米颗粒的疗法递送至皮肤需要特别考虑，特定技术不仅要考虑靶点，还要考虑递送途径。为精确解决这些问题而开发的一系列基于纳米颗粒的技术应对了这一独特挑战。在这篇综述文章中，我们描述了基于纳米颗粒的技术在皮肤靶向给药中的应用，总结了纳米颗粒的类型，并讨论了用于皮肤癌预防和皮肤癌治疗的纳米颗粒的当前情况以及这些应用的未来发展方向。
