Cátedra de Morfología Animal, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba.
J Oral Pathol Med. 2010 Jan;39(1):10-5. doi: 10.1111/j.1600-0714.2009.00806.x. Epub 2009 Jul 19.
Among the agents that cause parotid sialosis, diabetes mellitus type 2 and chronic alcoholism are included. In this study, the morphometrical modifications in the diabetic parotid sialosis were determined to compare them with the histopathological characteristics of alcoholic parotid sialosis.
Five parotid biopsy samples obtained from patients with diabetic sialosis, 12 samples from patients with alcoholic sialosis and seven from individuals without these pathologies (control group) were analyzed. A morphometrical study of parotid parenchyme and stroma, using a digital image analyzer attached to an optical microscope, was carried out. Dimensions of serous acini and striated ducts, the area occupied by the fatty tissue, and the number of ducts were recorded. Mean values were compared using the Mann-Whitney U-test (P <or= 0.05).
The variables analyzed in diabetic patients did not show significant differences with respect to the control group. However, when diabetics were compared with alcoholics, the alcoholics exhibited a noticeable reduction in the proportion of fatty tissue of stroma and a significant development of ductal epithelium that contributed to increase the caliber of the striated ducts.
These results indicate that the glandular hypertrophy in the diabetic parotid sialosis is not directly associated with the ductal and acinar size, amount of fatty tissue and ductal hyperplasy. Nevertheless, these findings show that the ductal dimensions and the proportion of adipose tissue are variables that allow us to establish histopathological differences between diabetic and alcoholic sialosis.
引起腮腺唾液腺病的因素包括 2 型糖尿病和慢性酒精中毒。在这项研究中，测定了糖尿病性腮腺唾液腺病的形态计量学改变，并将其与酒精性腮腺唾液腺病的组织病理学特征进行了比较。
分析了 5 例糖尿病性唾液腺病患者、12 例酒精性唾液腺病患者和 7 例无这些病理改变的个体（对照组）的腮腺活检样本。使用光学显微镜上附加的数字图像分析仪对腮腺实质和基质进行形态计量学研究。记录浆液性腺泡和纹状导管的尺寸、脂肪组织所占面积和导管数量。使用曼-惠特尼 U 检验（P≤0.05）比较平均值。
与对照组相比，糖尿病患者分析的变量没有显著差异。然而，当将糖尿病患者与酒精中毒患者进行比较时，酒精中毒患者的基质脂肪组织比例明显减少，导管上皮明显发育，导致纹状导管口径增大。
这些结果表明，糖尿病性腮腺唾液腺病的腺体肥大与导管和腺泡大小、脂肪组织含量和导管增生无关。然而，这些发现表明，导管尺寸和脂肪组织比例是可以用来确定糖尿病和酒精性唾液腺病之间组织病理学差异的变量。
