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1
Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.克隆鼠与人:禁止使用 iPS 细胞进行人类生殖性克隆。
Cell Stem Cell. 2010 Jan 8;6(1):16-20. doi: 10.1016/j.stem.2009.12.004.
2
Ethical concerns over use of new cloning technique in humans.对人类使用新克隆技术的伦理担忧。
Nature. 2009 Sep 17;461(7262):341. doi: 10.1038/461341b.
3
Induced pluripotent stem cells: how to deal with the developmental potential.诱导多能干细胞:如何应对其发育潜能。
Reprod Biomed Online. 2009;19 Suppl 1:34-7. doi: 10.1016/s1472-6483(10)60062-4.
4
Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation.通过四倍体补偿从诱导多能干细胞(iPSC)生成有活力的小鼠。
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5
Human procreation in unchartered territory: new twists in ethical discussions.人类在未知领域的繁衍:伦理讨论的新转折。
Hum Reprod. 2011 Jun;26(6):1284-7. doi: 10.1093/humrep/der093. Epub 2011 Apr 5.
6
Stemming the tide of cloning.遏制克隆的潮流。
First Things. 2005 Dec(158):6-9.
7
Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning.核转移以预防线粒体 DNA 疾病:重新审视生殖性克隆的争论。
Reprod Biomed Online. 2011 Feb;22(2):200-7. doi: 10.1016/j.rbmo.2010.10.016. Epub 2010 Nov 12.
8
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Nature. 2009 Jul 30;460(7255):560. doi: 10.1038/460560a.
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Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells.由成年体细胞来源的全能性 iPS 细胞生成的可育的有活力的小鼠。
Stem Cell Rev Rep. 2010 Sep;6(3):390-7. doi: 10.1007/s12015-010-9160-3.
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Dollywood is not just a theme park in Tennessee anymore: unwarranted prohibitory human cloning legislation and policy guidelines for a regulatory approach to cloning.多莱坞不再仅仅是田纳西州的一个主题公园了:毫无根据的禁止性人类克隆立法以及关于克隆监管方法的政策指南。
John Marshall Law Rev. 1998 Summer;31(4):1385-422.

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Lessons Learned from Somatic Cell Nuclear Transfer.体细胞细胞核移植的经验教训。
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Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations.诱导多能干细胞(iPSCs)的研究和治疗:社会、法律和伦理方面的考虑。
Stem Cell Res Ther. 2019 Nov 21;10(1):341. doi: 10.1186/s13287-019-1455-y.
4
The global governance of human cloning: the case of UNESCO.人类克隆的全球治理:以联合国教科文组织为例。
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Time to reconsider stem cell induction strategies.重新考虑干细胞诱导策略的时间到了。
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Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent.诱导多能干细胞研究的标本采集:协调知情同意书的方法。
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Expand and regularize federal funding for human pluripotent stem cell research.扩大并规范联邦政府对人类多能干细胞研究的资金投入。
J Policy Anal Manage. 2012;31(3):714-22. doi: 10.1002/pam.21607.
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Stem cell policy exceptionalism: proceed with caution.干细胞政策的例外主义:谨慎行事。
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10
Interspecies chimera between primate embryonic stem cells and mouse embryos: monkey ESCs engraft into mouse embryos, but not post-implantation fetuses.灵长类胚胎干细胞与小鼠胚胎之间的种间嵌合体:猴胚胎干细胞可植入小鼠胚胎,但不能植入植入后胎儿。
Stem Cell Res. 2011 Jul;7(1):28-40. doi: 10.1016/j.scr.2011.03.002. Epub 2011 Mar 25.

本文引用的文献

1
Ethical concerns over use of new cloning technique in humans.对人类使用新克隆技术的伦理担忧。
Nature. 2009 Sep 17;461(7262):341. doi: 10.1038/461341b.
2
Adult mice generated from induced pluripotent stem cells.由诱导多能干细胞产生的成年小鼠。
Nature. 2009 Sep 3;461(7260):91-4. doi: 10.1038/nature08310.
3
iPS cells produce viable mice through tetraploid complementation.诱导多能干细胞通过四倍体补偿产生存活的小鼠。
Nature. 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.
4
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.诱导多能干细胞可支持四倍体囊胚互补胚胎的足月发育。
Cell Stem Cell. 2009 Aug 7;5(2):135-8. doi: 10.1016/j.stem.2009.07.001. Epub 2009 Jul 23.
5
Induced pluripotent stem cells: how to deal with the developmental potential.诱导多能干细胞:如何应对其发育潜能。
Reprod Biomed Online. 2009;19 Suppl 1:34-7. doi: 10.1016/s1472-6483(10)60062-4.
6
VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos.快速小鼠:通过将胚胎干细胞注射到八细胞期胚胎中获得的完全由胚胎干细胞衍生的F0代小鼠。
Methods Mol Biol. 2009;530:311-24. doi: 10.1007/978-1-59745-471-1_16.
7
F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses.完全源自基因靶向胚胎干细胞的F0代小鼠可立即进行表型分析。
Nat Biotechnol. 2007 Jan;25(1):91-9. doi: 10.1038/nbt1263. Epub 2006 Dec 24.
8
Cloning and government regulation.克隆与政府监管。
Hastings Law J. 2002 Jul;53(5):1085-96.
9
Is there a constitutional right to clone?是否存在克隆的宪法权利?
Hastings Law J. 2002 Jul;53(5):987-1005.
10
The President's Council on Bioethics: human cloning and human dignity: an ethical inquiry--executive summary.总统生物伦理委员会:人类克隆与人类尊严:一项伦理调查——执行摘要
Issues Law Med. 2002 Fall;18(2):167-82.

克隆鼠与人:禁止使用 iPS 细胞进行人类生殖性克隆。

Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.

机构信息

Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA.

出版信息

Cell Stem Cell. 2010 Jan 8;6(1):16-20. doi: 10.1016/j.stem.2009.12.004.

DOI:10.1016/j.stem.2009.12.004
PMID:20085739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4035242/
Abstract

The use of iPSCs and tetraploid complementation for human reproductive cloning would raise profound ethical objections. Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation.

摘要

使用 iPS 细胞和四倍体互补技术进行人类生殖性克隆会引发深刻的伦理问题。专业标准和法律禁止使用体细胞核转移技术进行人类生殖性克隆,也应该修订这些标准和法律,禁止使用 iPS 细胞通过四倍体互补等其他方法进行人类生殖性克隆。