松果腺功能：微阵列分析的影响。
Pineal function: impact of microarray analysis.
机构信息
Section on Neuroendocrinology, Program on Developmental Endocrinology and Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Mol Cell Endocrinol. 2010 Jan 27;314(2):170-83. doi: 10.1016/j.mce.2009.07.010. Epub 2009 Jul 19.
Abstract
Microarray analysis has provided a new understanding of pineal function by identifying genes that are highly expressed in this tissue relative to other tissues and also by identifying over 600 genes that are expressed on a 24-h schedule. This effort has highlighted surprising similarity to the retina and has provided reason to explore new avenues of study including intracellular signaling, signal transduction, transcriptional cascades, thyroid/retinoic acid hormone signaling, metal biology, RNA splicing, and the role the pineal gland plays in the immune/inflammation response. The new foundation that microarray analysis has provided will broadly support future research on pineal function.
摘要
微阵列分析通过鉴定在该组织中相对于其他组织高度表达的基因，以及鉴定超过 600 个按照 24 小时时间表表达的基因，为理解松果腺功能提供了新的认识。这一努力突出了与视网膜惊人的相似性，并为探索新的研究途径提供了理由，包括细胞内信号转导、信号转导、转录级联、甲状腺/视黄酸激素信号转导、金属生物学、RNA 剪接以及松果腺在免疫/炎症反应中所起的作用。微阵列分析提供的新基础将广泛支持松果腺功能的未来研究。
相似文献
1
Pineal function: impact of microarray analysis.松果腺功能：微阵列分析的影响。
Mol Cell Endocrinol. 2010 Jan 27;314(2):170-83. doi: 10.1016/j.mce.2009.07.010. Epub 2009 Jul 19.
2
Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillator and pacemaker.雏鸡松果体的转录谱分析，松果体是一种光感受性昼夜节律振荡器和起搏器。
Mol Endocrinol. 2003 Oct;17(10):2084-95. doi: 10.1210/me.2003-0121. Epub 2003 Jul 24.
3
Circadian genomics of the chick pineal gland in vitro.鸡松果体体外昼夜节律基因组学
BMC Genomics. 2008 May 3;9:206. doi: 10.1186/1471-2164-9-206.
4
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.600多个基因在松果体中的昼夜表达变化：肾上腺素能/cAMP信号传导的核心作用
J Biol Chem. 2009 Mar 20;284(12):7606-22. doi: 10.1074/jbc.M808394200. Epub 2008 Dec 22.
5
The pineal gland from development to function.松果腺的发育与功能。
Curr Top Dev Biol. 2013;106:171-215. doi: 10.1016/B978-0-12-416021-7.00005-5.
6
Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina.硬骨鱼松果体器官和视网膜中褪黑素节律产生系统之间的遗传、时间和发育差异。
J Neuroendocrinol. 2003 Apr;15(4):378-82. doi: 10.1046/j.1365-2826.2003.00993.x.
7
Analysis of daily and circadian gene expression in the rat pineal gland.大鼠松果体中每日及昼夜节律基因表达的分析。
Neurosci Res. 2008 Feb;60(2):192-8. doi: 10.1016/j.neures.2007.10.011. Epub 2007 Nov 6.
8
The pineal and melatonin: regulators of circadian function in lower vertebrates.松果体与褪黑素：低等脊椎动物昼夜节律功能的调节因子。
Experientia. 1990 Jan 15;46(1):120-8. doi: 10.1007/BF01955437.
9
cDNA array analysis of pineal gene expression reveals circadian rhythmicity of the dominant negative helix-loop-helix protein-encoding gene, Id-1.松果体基因表达的cDNA阵列分析揭示了显性负性螺旋-环-螺旋蛋白编码基因Id-1的昼夜节律性。
J Neuroendocrinol. 2002 Feb;14(2):101-8. doi: 10.1046/j.0007-1331.2001.00738.x.
10
The pineal gland and cancer.松果体与癌症。
Anticancer Res. 1996 Jul-Aug;16(4A):2033-9.
引用本文的文献
1
Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.环状 RNA ERC2 通过调控 miR-125a-5p/MAT2A 轴参与褪黑素的合成。
Int J Mol Sci. 2022 Dec 7;23(24):15477. doi: 10.3390/ijms232415477.
2
The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes.大鼠松果体细胞中的 Lhx4 同源盒转录物：肾上腺素能调节及其对编码褪黑素合成酶的转录物的影响。
J Pineal Res. 2020 Jan;68(1):e12616. doi: 10.1111/jpi.12616. Epub 2019 Nov 11.
3
Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression.褪黑素对吗啡耐受逆转过程中转录的调节：差异基因表达的微阵列分析。
Int J Mol Med. 2019 Feb;43(2):791-806. doi: 10.3892/ijmm.2018.4030. Epub 2018 Dec 18.
4
Differential response of pineal microglia to surgical versus pharmacological stimuli.松果体小胶质细胞对手术刺激与药物刺激的差异反应。
J Comp Neurol. 2018 Oct 15;526(15):2462-2481. doi: 10.1002/cne.24505. Epub 2018 Sep 24.
5
Foxg1 deletion impairs the development of the epithalamus.Foxg1 缺失会损害顶盖的发育。
Mol Brain. 2018 Feb 2;11(1):5. doi: 10.1186/s13041-018-0350-2.
6
Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program.日常皮质酮节律通过 NFκB 相关基因转录程序调节松果腺功能。
Sci Rep. 2017 May 18;7(1):2091. doi: 10.1038/s41598-017-02286-y.
7
The pineal gland: A model for adrenergic modulation of ubiquitin ligases.松果体：泛素连接酶肾上腺素能调节的一个模型。
PLoS One. 2017 Feb 17;12(2):e0172441. doi: 10.1371/journal.pone.0172441. eCollection 2017.
8
Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation.使用多平台测序方法对大鼠松果体中Ttc8表达的可变异构体分析揭示了神经调节。
PLoS One. 2016 Sep 29;11(9):e0163590. doi: 10.1371/journal.pone.0163590. eCollection 2016.
9
Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland.褪黑素合成：乙酰血清素O-甲基转移酶（ASMT）在雄性大鼠松果体的一部分松果体细胞中强烈表达。
Endocrinology. 2016 May;157(5):2028-40. doi: 10.1210/en.2015-1888. Epub 2016 Mar 7.
10
A Pit-1 Binding Site Adjacent to E-box133 in the Rat PRL Promoter is Necessary for Pulsatile Gene Expression Activity.大鼠催乳素启动子中与E-box133相邻的Pit-1结合位点对脉冲式基因表达活性是必需的。
Neurochem Res. 2016 Jun;41(6):1390-400. doi: 10.1007/s11064-016-1843-y. Epub 2016 Feb 15.
本文引用的文献
1
Transcriptome analysis of the zebrafish pineal gland.斑马鱼松果体的转录组分析。
Dev Dyn. 2009 Jul;238(7):1813-26. doi: 10.1002/dvdy.21988.
2
Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).甲状腺激素和肾上腺素能信号相互作用以控制松果体中多巴胺受体 D4 基因（Drd4）的表达。
Mol Cell Endocrinol. 2010 Jan 15;314(1):128-35. doi: 10.1016/j.mce.2009.05.013. Epub 2009 May 29.
3
Salt-inducible kinase 1 in the rat pinealocyte: adrenergic regulation and role in arylalkylamine N-acetyltransferase gene transcription.大鼠松果体细胞中的盐诱导激酶1：肾上腺素能调节及其在芳基烷基胺N-乙酰基转移酶基因转录中的作用。
Endocrinology. 2009 Sep;150(9):4221-30. doi: 10.1210/en.2009-0275. Epub 2009 May 21.
4
Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism.肌肉失明样蛋白2：哺乳动物松果体中的昼夜节律表达受肾上腺素能-cAMP机制控制。
J Neurochem. 2009 Jul;110(2):756-64. doi: 10.1111/j.1471-4159.2009.06184.x. Epub 2009 May 19.
5
Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells.多巴胺D4受体和1型腺苷酸环化酶在光感受器细胞中环磷酸腺苷的光控作用中的重要作用。
J Neurochem. 2009 Apr;109(1):148-57. doi: 10.1111/j.1471-4159.2009.05920.x. Epub 2009 Jan 22.
6
A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland.一种驱动斑马鱼松果体基因表达的新型顺式作用调控元件。
Bioinformatics. 2009 Mar 1;25(5):559-62. doi: 10.1093/bioinformatics/btp031. Epub 2009 Jan 15.
7
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.600多个基因在松果体中的昼夜表达变化：肾上腺素能/cAMP信号传导的核心作用
J Biol Chem. 2009 Mar 20;284(12):7606-22. doi: 10.1074/jbc.M808394200. Epub 2008 Dec 22.
8
Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.大鼠视网膜中Pax4和Pax6同源框基因的发育及日常表达：Pax4在光感受器细胞中的定位
J Neurochem. 2009 Jan;108(1):285-94. doi: 10.1111/j.1471-4159.2008.05765.x. Epub 2008 Nov 19.
9
Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling.哺乳动物松果体中Pax4表达的发育和昼夜动态变化：夜间下调由肾上腺素能 - 环磷酸腺苷信号介导。
Endocrinology. 2009 Feb;150(2):803-11. doi: 10.1210/en.2008-0882. Epub 2008 Sep 25.
10
Analysis of daily and circadian gene expression in the rat pineal gland.大鼠松果体中每日及昼夜节律基因表达的分析。
Neurosci Res. 2008 Feb;60(2):192-8. doi: 10.1016/j.neures.2007.10.011. Epub 2007 Nov 6.
Zotero 插件