基底节核萎缩与颞叶癫痫的阴性症状。
Atrophy of basal ganglia nuclei and negative symptoms in temporal lobe epilepsy.
机构信息
Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2009 Spring;21(2):152-9. doi: 10.1176/jnp.2009.21.2.152.
Abstract
Recent work has identified the presence of negative symptoms in a subset of temporal lobe epilepsy (TLE) patients. The authors hypothesized that negative symptoms in TLE are associated with disruption in the mesolimbic system. Basal ganglia and anterior cingulate region of interest volumes were compared between 22 TLE patients with negative symptoms, 22 TLE patients without negative symptoms, and 22 comparison subjects. The negative symptom group showed significantly reduced volumes in the putamen and globus pallidus. It appears that these structures within the broader mesolimbic system contribute to the phenomenon of negative symptoms in TLE.
摘要
最近的研究发现，一部分颞叶癫痫（TLE）患者存在阴性症状。作者假设 TLE 中的阴性症状与中脑边缘系统的紊乱有关。对 22 例有阴性症状的 TLE 患者、22 例无阴性症状的 TLE 患者和 22 例对照受试者的基底节和前扣带回感兴趣区体积进行了比较。阴性症状组的壳核和苍白球体积明显减小。似乎中脑边缘系统内的这些结构有助于解释 TLE 中的阴性症状现象。
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