Department of Psychiatry, The University of Texas Health Science Center, 7703 Floyd Curl Dr., Mail code: 7792, San Antonio, TX 78229-3900, USA.
J Neuropsychiatry Clin Neurosci. 2009 Spring;21(2):173-80. doi: 10.1176/jnp.2009.21.2.173.
Forty percent of nondemented octogenarians have Braak stages consistent with insular involvement, and may be at risk for "age-related" autonomic dysfunction. The authors examined the association between insular resting cerebral blood flow (rCBF) and cardiovascular functions in 29 nondemented elderly subjects who were highly screened to exclude comorbid cardiovascular disease. Mean insular rCBF was significantly higher on the right than left. However, 35.4% of participants had left dominant rCBF (a high-risk group). Right insular rCBF was significantly lower in the high-risk group. This subset had significantly increased positional drops in systolic blood pressure. While these data cannot address Alzheimer's disease as the specific cause, this possibility is being investigated in other cohorts.
40%的非痴呆 80 岁以上老年人存在与岛叶受累一致的 Braak 分期，可能存在与“年龄相关”的自主神经功能障碍风险。作者在 29 名经过严格筛选以排除合并心血管疾病的非痴呆老年人中，检查了岛叶静息脑血流 (rCBF)与心血管功能之间的关联。右侧岛叶 rCBF 明显高于左侧，但 35.4%的参与者存在左侧优势 rCBF（高风险组）。高风险组右侧岛叶 rCBF 明显降低。这部分人群体位性收缩压下降明显增加。虽然这些数据不能确定阿尔茨海默病是特定的病因，但正在其他队列中对此可能性进行研究。
