Brownson Carol A, Hoerger Thomas J, Fisher Edwin B, Kilpatrick Kerry E
The National Program Office of the Robert Wood Johnson Foundation Diabetes Initiative, Division of Health Behavior Research, Washington University School of Medicine in St Louis, St Louis, Missouri (Ms Brownson)
Research Triangle Institute International (RTI), RTI–University of North Carolina Center of Excellence in Health Promotion Economics, Research Triangle Park, North Carolina (Dr Hoerger)
Diabetes Educ. 2009 Sep-Oct;35(5):761-9. doi: 10.1177/0145721709340931. Epub 2009 Jul 21.
The purpose of this study is to estimate the cost-effectiveness of diabetes self-management programs in real-world community primary care settings. Estimates incorporated lifetime reductions in disease progression, costs of adverse events, and increases in quality of life.
Clinical results and costs were based on programs of the Diabetes Initiative of the Robert Wood Johnson Foundation, implemented in primary care and community settings in disadvantaged areas with notable health disparities. Program results were used as inputs to a Markov simulation model to estimate the long-term effects of self-management interventions. A health systems perspective was adopted.
The simulation model estimates that the intervention does reduce discounted lifetime treatment and complication costs by $3385, but this is more than offset by the $15,031 cost of implementing the intervention and maintaining its effects in subsequent years. The intervention is estimated to reduce long-term complications, leading to an increase in remaining life-years and quality-adjusted life-years (QALYs). The incremental cost-effectiveness ratio is $39,563/QALY, well below a common benchmark of $50,000/QALY. Sensitivity analyses tested the robustness of the model's estimates under various alternative assumptions. The model generally predicts acceptable cost-effectiveness ratios.
Self-management programs for type 2 diabetes are cost-effective from a health systems perspective when the cost savings due to reductions in long-term complications are recognized. These findings may justify increased reimbursement for effective self-management programs in diverse settings.
本研究旨在评估糖尿病自我管理项目在现实社区初级保健环境中的成本效益。评估纳入了疾病进展的终身减少、不良事件成本以及生活质量的提高。
临床结果和成本基于罗伯特·伍德·约翰逊基金会糖尿病倡议项目,该项目在健康差距显著的贫困地区的初级保健和社区环境中实施。项目结果被用作马尔可夫模拟模型的输入,以估计自我管理干预的长期效果。采用卫生系统视角。
模拟模型估计,干预措施确实使贴现后的终身治疗和并发症成本降低了3385美元,但实施干预措施并在随后几年维持其效果的15031美元成本远远超过了这一节省。据估计,该干预措施可减少长期并发症,从而增加剩余寿命年数和质量调整生命年数(QALYs)。增量成本效益比为39563美元/QALY,远低于50000美元/QALY的常见基准。敏感性分析在各种替代假设下测试了模型估计的稳健性。该模型通常预测可接受的成本效益比。
从卫生系统的角度来看,当认识到由于长期并发症减少而节省的成本时,2型糖尿病的自我管理项目具有成本效益。这些发现可能证明在不同环境中增加对有效自我管理项目的报销是合理的。