Dorn Spencer D, Morris Carolyn B, Hu Yuming, Toner Brenda B, Diamant Nicholas, Whitehead William E, Bangdiwala Shrikant I, Drossman Douglas A
UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7080, USA.
J Clin Gastroenterol. 2009 Mar;43(3):214-20. doi: 10.1097/MCG.0b013e31815bd749.
The implications of the Rome III recommendations to change the irritable bowel syndrome (IBS) subtype criteria for stool pattern are unknown.
(1) Determine the level of agreement between Rome II and Rome III subtypes and (2) compare the behaviors of Rome II and Rome III subtypes over time.
Female patients (n=148) with Rome II defined IBS were prospectively tracked over 5 consecutive 3-month periods. At baseline, bowel habit reports on questionnaires were used to subclassify patients into Rome II and Rome III subtypes. Over the subsequent 15 months, bowel habit reports on diary cards were used to subclassify patients based on previously derived surrogate criteria into Rome II and Rome III IBS subtypes.
The level of agreement between Rome II and Rome III subtype assignments was quite high (86.5%; kappa 0.79). The behavior of Rome II and Rome III subtypes over time was also similar in terms of subtype prevalence, subtype stability, and the proportion of subjects who met criteria for alternating irritable bowel syndrome.
Rome II and Rome III IBS subtypes are in high agreement and behave similarly over time. Therefore, studies that used Rome II subtype criteria and studies that will use Rome III criteria will define comparable populations.
罗马III标准对肠易激综合征（IBS）粪便模式亚型标准进行更改的影响尚不清楚。
（1）确定罗马II型和罗马III型亚型之间的一致性水平，以及（2）比较罗马II型和罗马III型亚型随时间的变化情况。
对148名符合罗马II标准的女性IBS患者进行连续5个为期3个月的前瞻性跟踪研究。在基线时，通过问卷调查中的排便习惯报告将患者分为罗马II型和罗马III型亚型。在随后的15个月中，根据日记卡上的排便习惯报告，依据先前得出的替代标准将患者分为罗马II型和罗马III型IBS亚型。
罗马II型和罗马III型亚型分类之间的一致性水平相当高（86.5%；kappa值为0.79）。在亚型患病率、亚型稳定性以及符合交替性肠易激综合征标准的受试者比例方面，罗马II型和罗马III型亚型随时间的变化情况也相似。
罗马II型和罗马III型IBS亚型高度一致，且随时间变化情况相似。因此，采用罗马II型亚型标准的研究和采用罗马III型标准的研究将界定可比人群。
