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Changes in age at menarche in Germany: Evidence for a continuing decline.德国初潮年龄的变化:持续下降的证据。
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Environmental factors and puberty timing: expert panel research needs.环境因素与青春期发育时间:专家小组的研究需求
Pediatrics. 2008 Feb;121 Suppl 3:S192-207. doi: 10.1542/peds.1813E.
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The genetic aetiology of Silver-Russell syndrome.Silver-Russell综合征的遗传病因学。
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Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off.母性行为和药物干预引起的表观遗传编程。先天与后天:让我们别再争论了。
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Genome partitioning of genetic variation for height from 11,214 sibling pairs.对11214对同胞兄弟姐妹的身高遗传变异进行基因组分区。
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The mysterious trend in American heights in the 20th century.20世纪美国身高出现的神秘趋势。
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Are universal standards for optimal infant growth appropriate? Evidence from a Hong Kong Chinese birth cohort.最佳婴儿生长的通用标准是否合适?来自香港华裔出生队列的证据。
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Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?转录的表观遗传调控:一种因生命早期营养差异而诱导表型变异(胎儿编程)的机制?
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德国儿童的生长发育与青春期:是否仍存在积极的长期趋势?

Growth and puberty in German children: is there still a positive secular trend?

作者信息

Gohlke Bettina, Woelfle Joachim

机构信息

Pädiatrische Endokrinologie und Diabetologie, Abteilung für Allgemeine Pädiatrie am Zentrum für Kinderheilkunde der Universität Bonn, Germany.

出版信息

Dtsch Arztebl Int. 2009 Jun;106(23):377-82. doi: 10.3238/arztebl.2009.0377. Epub 2009 Jun 5.

DOI:10.3238/arztebl.2009.0377
PMID:19623318
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2712240/
Abstract

BACKGROUND

Since the mid-19th century, growth in German children has accelerated and final height increased. Possible causes of this secular trend include improvements in nutrition, hygiene, and health care. While the upward secular trend still continues in some parts of the world, it seems to be slowing in industrialized countries.

METHODS

Selective literature review.

RESULTS

Reliable data on growth that have been published since the middle of the 19th century reveal an increase in final height by 1 to 2 cm per decade in most European countries. Recent epidemiological studies, however, suggest that human height may be nearing an upper limit, beyond which it cannot increase even with further improvements in nutrition and health care. In Germany and other northern European countries, the upward trend in final height has slowed significantly over the last 30 years; in Germany, it now stands at less than 1 cm/decade. In the same interval, the age at menarche has remained constant at just under 13 years (currently 12.8).

CONCLUSIONS

In Germany, as elsewhere in northern Europe, the upward secular trend in height is slowing (ca. 2 cm/decade up to the mid-20th century, currently less than 1 cm/decade), and the age at menarche has stabilized at just under 13 years. It remains an open question whether the observed slowing will merely be temporary, or whether it indeed represents the near-attainment of an endpoint owing to relatively stable environmental conditions.

摘要

背景

自19世纪中叶以来,德国儿童的生长加速,最终身高增加。这种长期趋势的可能原因包括营养、卫生和医疗保健的改善。虽然这种上升的长期趋势在世界某些地区仍在继续,但在工业化国家似乎正在放缓。

方法

选择性文献综述。

结果

自19世纪中叶以来发表的可靠生长数据显示,大多数欧洲国家的最终身高每十年增加1至2厘米。然而,最近的流行病学研究表明,人类身高可能接近上限,即使营养和医疗保健进一步改善,身高也无法再增加。在德国和其他北欧国家,最终身高的上升趋势在过去30年中显著放缓;在德国,目前已降至每十年不到1厘米。在同一时期,初潮年龄一直稳定在略低于13岁(目前为12.8岁)。

结论

在德国,与北欧其他地方一样,身高的长期上升趋势正在放缓(20世纪中叶前约为每十年2厘米,目前不到每十年1厘米),初潮年龄已稳定在略低于13岁。观察到的放缓是仅仅是暂时的,还是由于环境条件相对稳定确实代表接近终点,这仍是一个悬而未决的问题。