Benthin M, Dahl P, Ruzicka R, Lindström K
Department of Electrical Measurements, Lund Institute of Technology, Sweden.
Ultrasound Med Biol. 1991;17(5):461-9. doi: 10.1016/0301-5629(91)90182-v.
The need to investigate the elastic properties of arterial vessels in situ for the early recognition of degenerative disorders in arteries has long been apparent. Pulse-wave diagnostics has been used in traditional medicine, but only in a qualitative way. By measuring the vessel diameter change, simultaneously at two levels along an artery, it should be possible to calculate the pulse-wave velocity (PWV). A newly developed ultrasonic instrument, DIAMOVE, was designed to provide a two-dimensional, real time, B-mode image for display of the exact position of two measurement sites; a computer-controlled digital phased-locked loop detector for the measurement of diameter changes; and a personal computer for the display of the momentary displacement of the artery walls. The cross-correlation technique was used on the information from the vessel wall movements to calculate the resulting PWV. Early measurements on healthy patients showed some unexpected artifacts, which were found to be due to reflected waves, affecting the shape of the pulse-wave at the sites of measurement. A modified PWV estimation algorithm, where only the foot of the pulse-wave in every beat is utilized, seems to have solved this problem and now makes the method suitable for clinical use.
长期以来，原位研究动脉血管的弹性特性以早期识别动脉退行性疾病的需求一直很明显。脉搏波诊断已在传统医学中使用，但仅以定性方式使用。通过沿动脉在两个水平同时测量血管直径变化，应该能够计算脉搏波速度（PWV）。一种新开发的超声仪器DIAMOVE旨在提供二维实时B模式图像，以显示两个测量部位的确切位置；一个计算机控制的数字锁相环探测器，用于测量直径变化；以及一台个人计算机，用于显示动脉壁的瞬时位移。利用互相关技术对来自血管壁运动的信息进行处理，以计算得出的PWV。对健康患者的早期测量显示出一些意外的伪像，发现这些伪像是由反射波引起的，影响了测量部位脉搏波的形状。一种改进的PWV估计算法，其中仅利用每个搏动中脉搏波的波谷，似乎已经解决了这个问题，现在使该方法适用于临床应用。
