生物信息学在蛋白质结构中的应用：蛋白质结构与生物信息学如何相互重叠。
Applications of bioinformatics to protein structures: how protein structure and bioinformatics overlap.
作者信息
Han Gye Won, Rife Chris, Sawaya Michael R
机构信息
Burnham Institute for Medical Research, La Jolla, CA, USA.
出版信息
Methods Mol Biol. 2009;569:157-72. doi: 10.1007/978-1-59745-524-4_8.
In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Then, we discuss how to analyze protein-protein interfaces and how to predict the biomolecule which is the biological oligomeric state of the protein. Finally, we discuss how to search for homologs based on the 3-D structure which is an essential step for understanding protein function.
在本章中，我们将重点关注生物信息学在蛋白质结构确定后对其进行分析的作用。首先，我们介绍如何为保证质量而验证蛋白质结构。然后，我们讨论如何分析蛋白质-蛋白质相互作用界面以及如何预测作为蛋白质生物学寡聚状态的生物分子。最后，我们讨论如何基于三维结构搜索同源物，这是理解蛋白质功能的关键步骤。
Zotero 插件