Mathew Praveen, Bhatia Shobna J
Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.
Trop Gastroenterol. 2009 Jan-Mar;30(1):19-25.
The exact cause of irritable bowel syndrome (IBS) is not known. Multiple factors, like genetic, gut motility, visceral hypersensitivity, psychosocial factors and immune-mediated factors, are thought to contribute to the symptom complex of IBS. Till date an 'IBS gene' has not been defined, and there is a need for further studies. The concept that IBS as a diagnosis of exclusion is not acceptable any more. The treatment of IBS is targeted at the management of constipation, diarrhoea and abdominal pain and includes pharmacotherapy with tegaserod, alosetron and lubiprostone. Cognitive behavioral therapy is very beneficial.
肠易激综合征（IBS）的确切病因尚不清楚。多种因素，如遗传、肠道动力、内脏高敏感性、心理社会因素和免疫介导因素，被认为与肠易激综合征的症状复合体有关。迄今为止，尚未确定“肠易激综合征基因”，因此需要进一步研究。肠易激综合征作为排除性诊断的概念已不再被接受。肠易激综合征的治疗针对便秘、腹泻和腹痛的管理，包括使用替加色罗、阿洛司琼和鲁比前列酮进行药物治疗。认知行为疗法非常有益。
