Zabel R, Ash S, King N, Bauer J
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Qld, Australia.
J Hum Nutr Diet. 2009 Aug;22(4):343-50. doi: 10.1111/j.1365-277X.2009.00968.x.
Poor appetite is a marker of morbidity and mortality in haemodialysis patients, making it an important area for research. Visual analogue scales (VAS) can capture a range of subjective sensations related to appetite (such as hunger, desire to eat or fullness), but have not been commonly used to measure appetite in dialysis patients. The present study aimed to explore the association between retrospective ratings of appetite using VAS and a range of clinical variables, as well as biomarkers of appetite in haemodialysis patients.
Twenty-eight haemodialysis patients [mean age 61 +/- 17 years, 50% male, median dialysis vintage 19.5 (4-101) months] rated their appetite using VAS for hunger, fullness and desire to eat and a five-point categorical scale measuring general appetite. Blood levels of the appetite peptides leptin, ghrelin and peptide YY were also measured.
Hunger ratings measured by VAS were significantly (P < 0.05) correlated with a range of clinical, nutritional and inflammatory markers: age (r = -0.376), co-morbidities, (r = -0.380) Patient-Generated Subjective Global Assessment score (r = -0.451), weight (r = -0.375), fat-free mass (r = -0.435), C-reactive protein (r = -0.383) and intercellular adhesion molecule (r = -0.387). There was a consistent relationship between VAS and appetite on a five-point categorical scale for questions of hunger, and a similar trend for desire to eat, but not for fullness. Neither method for measuring subjective appetite correlated with appetite peptides.
Retrospective ratings of hunger on a VAS are associated with a range of clinical variables and further studies are warranted to support their use as a method for measuring appetite in dialysis patients.
食欲不佳是血液透析患者发病和死亡的一个指标，使其成为一个重要的研究领域。视觉模拟量表（VAS）可以捕捉一系列与食欲相关的主观感受（如饥饿感、进食欲望或饱腹感），但尚未普遍用于测量透析患者的食欲。本研究旨在探讨使用VAS进行食欲回顾性评分与一系列临床变量以及血液透析患者食欲生物标志物之间的关联。
28名血液透析患者[平均年龄61±17岁，50%为男性，透析中位时间19.5（4 - 101）个月]使用VAS对饥饿感、饱腹感和进食欲望进行食欲评分，并使用五点分类量表测量总体食欲。还测量了食欲肽瘦素、胃饥饿素和肽YY的血液水平。
VAS测量的饥饿评分与一系列临床、营养和炎症标志物显著相关（P < 0.05）：年龄（r = -0.376）、合并症（r = -0.380）、患者主观整体评估得分（r = -0.451）、体重（r = -0.375）、去脂体重（r = -0.435）、C反应蛋白（r = -0.383）和细胞间黏附分子（r = -0.387）。在关于饥饿问题的五点分类量表上，VAS与食欲之间存在一致关系，进食欲望也有类似趋势，但饱腹感方面没有。两种测量主观食欲的方法均与食欲肽无关。
VAS上的饥饿回顾性评分与一系列临床变量相关，有必要进行进一步研究以支持将其作为测量透析患者食欲的一种方法。
