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预测黑色素瘤的预后:我们现在在哪里?

Predicting outcome in melanoma: where are we now?

机构信息

Department of Dermatology, Beaumont Hospital, Beaumont, Dublin, Ireland.

出版信息

Br J Dermatol. 2009 Sep;161(3):496-503. doi: 10.1111/j.1365-2133.2009.09324.x. Epub 2009 Jun 4.

DOI:10.1111/j.1365-2133.2009.09324.x
PMID:19624540
Abstract

Melanoma incidence continues to rise in most countries. This is of grave concern, given the mortality rate in a relatively young population. Current staging tools are limited in their ability to predict accurately those at risk of metastatic disease, relapse and treatment failure. This overview comprehensively reviews relevant literature, with the focus on the last 5 years, and discusses the current state of traditional and emerging novel methods of staging for melanoma and their effect on prognosis in this population.

摘要

黑色素瘤的发病率在大多数国家仍持续上升。鉴于相对年轻的人群中存在较高的死亡率,这一情况令人严重关切。目前的分期工具在准确预测发生转移性疾病、复发和治疗失败风险方面能力有限。本综述全面回顾了相关文献,重点关注过去 5 年的文献,并讨论了黑色素瘤传统和新兴分期方法的现状及其对该人群预后的影响。

相似文献

1
Predicting outcome in melanoma: where are we now?预测黑色素瘤的预后:我们现在在哪里?
Br J Dermatol. 2009 Sep;161(3):496-503. doi: 10.1111/j.1365-2133.2009.09324.x. Epub 2009 Jun 4.
2
Utility of computed tomography and magnetic resonance imaging staging before completion lymphadenectomy in patients with sentinel lymph node-positive melanoma.前哨淋巴结阳性黑色素瘤患者在完成淋巴结清扫术前计算机断层扫描和磁共振成像分期的效用
J Clin Oncol. 2006 Jun 20;24(18):2858-65. doi: 10.1200/JCO.2006.05.6176.
3
Expression pattern of the lymphatic and vascular markers VEGFR-3 and CD31 does not predict regional lymph node metastasis in cutaneous melanoma.淋巴管和血管标志物VEGFR-3和CD31的表达模式不能预测皮肤黑色素瘤的区域淋巴结转移。
Arch Dermatol Res. 2006 Feb;297(8):352-7. doi: 10.1007/s00403-005-0633-1. Epub 2006 Jan 3.
4
Tumor lymphangiogenesis and melanoma metastasis.肿瘤淋巴管生成与黑色素瘤转移。
J Cell Physiol. 2008 Aug;216(2):347-54. doi: 10.1002/jcp.21494.
5
Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases.在伴有黑色素瘤微转移的前哨淋巴结中对黑素细胞分化抗原和血管生成生物标志物进行高灵敏度多变量检测。
Arch Dermatol. 2009 Oct;145(10):1105-13. doi: 10.1001/archdermatol.2009.209.
6
Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis.年轻患者的黑色素瘤:与成人黑色素瘤的异同:病例匹配对照分析
Cancer. 2007 Aug 1;110(3):614-24. doi: 10.1002/cncr.22818.
7
[Important prognostic significance of a sentinel-node biopsy in patients with malignant melanoma].[前哨淋巴结活检对恶性黑色素瘤患者的重要预后意义]
Ned Tijdschr Geneeskd. 2004 May 1;148(18):884-8.
8
Predicting sentinel node status in AJCC stage I/II primary cutaneous melanoma.预测美国癌症联合委员会(AJCC)I/II期原发性皮肤黑色素瘤前哨淋巴结状态。
Cancer. 2006 Nov 15;107(10):2436-45. doi: 10.1002/cncr.22295.
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Our experience of melanoma thickness as a predictor of outcome of sentinel node biopsy.我们关于黑色素瘤厚度作为前哨淋巴结活检结果预测指标的经验。
Coll Antropol. 2008 Oct;32 Suppl 2:57-60.
10
Stratification of patients by melanoma cell adhesion molecule (MCAM) expression on the basis of risk: implications for sentinel lymph node biopsy.根据风险对黑色素瘤细胞粘附分子(MCAM)表达的患者进行分层:对前哨淋巴结活检的意义。
J Plast Reconstr Aesthet Surg. 2008;61(3):265-71. doi: 10.1016/j.bjps.2007.04.010. Epub 2007 Jun 13.

引用本文的文献

1
Inflammation markers in cutaneous melanoma - edgy biomarkers for prognosis.皮肤黑色素瘤中的炎症标志物——用于预后评估的前沿生物标志物
Discoveries (Craiova). 2015 Mar 27;3(1):e38. doi: 10.15190/d.2015.30.
2
Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma.超声、CT、MRI或PET-CT用于成人皮肤黑色素瘤的分期及再分期。
Cochrane Database Syst Rev. 2019 Jul 1;7(7):CD012806. doi: 10.1002/14651858.CD012806.pub2.
3
Metabolomic identification of diagnostic serum-based biomarkers for advanced stage melanoma.
代谢组学鉴定晚期黑色素瘤基于血清的诊断生物标志物。
Metabolomics. 2018 Aug 3;14(8):105. doi: 10.1007/s11306-018-1398-9.
4
Dabrafenib plus trametinib for compassionate use in metastatic melanoma: A STROBE-compliant retrospective observational postauthorization study.达拉非尼联合曲美替尼用于转移性黑色素瘤同情用药:一项符合STROBE标准的回顾性观察性上市后研究。
Medicine (Baltimore). 2017 Dec;96(52):e9523. doi: 10.1097/MD.0000000000009523.
5
Established and Emerging Biomarkers in Cutaneous Malignant Melanoma.在皮肤恶性黑色素瘤中的既定和新兴生物标志物。
Healthcare (Basel). 2014 Jan 14;2(1):60-73. doi: 10.3390/healthcare2010060.
6
Optimization of antitumor modulators of pre-mRNA splicing.优化前体 mRNA 剪接的抗肿瘤调节剂。
J Med Chem. 2013 Dec 27;56(24):10033-44. doi: 10.1021/jm401370h. Epub 2013 Dec 11.
7
A novel aliphatic 18F-labeled probe for PET imaging of melanoma.一种用于黑色素瘤正电子发射断层显像(PET)成像的新型脂肪族18F标记探针。
Mol Pharm. 2013 Sep 3;10(9):3384-91. doi: 10.1021/mp400225s. Epub 2013 Aug 22.
8
Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients.全基因组甲基化谱作为 IIIC 期黑色素瘤患者生存的独立标志物。
J Transl Med. 2012 Sep 5;10:185. doi: 10.1186/1479-5876-10-185.
9
Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer.使用[¹⁰F]ICF01006 对实验性原发性和播散性黑色素瘤进行早期检测和纵向监测,这是一种很有前途的黑色素瘤 PET 示踪剂。
Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1449-61. doi: 10.1007/s00259-012-2168-y. Epub 2012 Jun 16.
10
CDH22 expression is reduced in metastatic melanoma.CDH22在转移性黑色素瘤中的表达降低。
Am J Cancer Res. 2011;1(2):233-239. Epub 2010 Dec 10.