Bouvet L, Stoian A, Rimmelé T, Allaouchiche B, Chassard D, Boselli E
Claude Bernard University, University of Lyon, Lyon, France.
Anaesthesia. 2009 Jul;64(7):719-26. doi: 10.1111/j.1365-2044.2009.05916.x.
This dose-response study aimed to determine the dose of remifentanil combined with propofol 2.5 mg.kg(-1) which provided excellent intubation conditions in 95% of patients. Ninety premedicated female ASA 1 and 2 patients were randomly allocated to five remifentanil dose groups (1, 2, 3, 4 or 5 microg.kg(-1)). Induction of anaesthesia was performed with a blinded dose of remifentanil infused over 60 s simultaneously co-administered with propofol 2.5 mg.kg(-1) infused over 45 s. Tracheal intubation was attempted 150 s after the beginning of induction. Intubating conditions were assessed with the Copenhagen score. A probit analysis was performed to calculate the intubating efficient doses (IED) of remifentanil in 95% of patients (IED(95)). Our data revealed that the IED(95) of remifentanil was 4.0 (95% CI: 3.4-5.6) microg.kg(-1), which was associated with a maximum decrease in heart rate and mean arterial pressure of < 30%, a finding which also applied to the other groups.
这项剂量反应研究旨在确定瑞芬太尼与2.5mg.kg（-1）丙泊酚联合使用时的剂量，该剂量能使95%的患者达到良好的插管条件。90例接受术前用药的ASA 1级和2级女性患者被随机分配到五个瑞芬太尼剂量组（1、2、3、4或5μg.kg（-1））。麻醉诱导采用盲法给予瑞芬太尼，在60秒内输注，同时给予2.5mg.kg（-1）丙泊酚在45秒内输注。诱导开始150秒后尝试气管插管。插管条件采用哥本哈根评分进行评估。进行概率分析以计算95%患者中瑞芬太尼的插管有效剂量（IED）（IED（95））。我们的数据显示，瑞芬太尼的IED（95）为4.0（95%CI：3.4 - 5.6）μg.kg（-1），这与心率和平均动脉压最大下降<30%相关，这一结果也适用于其他组。
