Kawada Ryosaku, Yoshizumi Miho, Hirao Kazuyuki, Fujiwara Hironobu, Miyata Jun, Shimizu Mitsuaki, Namiki Chihiro, Sawamoto Nobukatsu, Fukuyama Hidenao, Hayashi Takuji, Murai Toshiya
Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Oct 1;33(7):1255-60. doi: 10.1016/j.pnpbp.2009.07.014. Epub 2009 Jul 19.
Behaviors associated with frontal/executive impairments are common in patients with schizophrenia. Our aim was to reconfirm that morphological brain abnormalities in schizophrenia patients would overlap the areas underpinning frontal systems behavior, and examine whether any specific association exists between abnormalities of brain structures and frontal behavioral deficits in schizophrenia patients.
Twenty-six schizophrenia patients and 26 matched healthy controls underwent structural magnetic resonance imaging and their frontal function was assessed by a self-rating questionnaire, Frontal Systems Behavior Scale (FrSBe). We applied voxel-based morphometry (VBM) to investigate regional brain volume alternations.
Compared with healthy controls, schizophrenia patients showed reduced gray matter volume in multiple frontal and temporal structures, namely, the bilateral dorsolateral prefrontal cortices (DLPFC), bilateral medial prefrontal cortices, left ventrolateral prefrontal cortex, bilateral anterior cingulate cortices, and bilateral superior temporal gyri. The scores on the executive dysfunction subscale of the FrSBe were correlated with volume reduction in the bilateral DLPFC in the patient group.
Our result suggests that pathology of the DLPFC could be the neural basis of real-life dysexecutive behaviors in schizophrenia patients.
精神分裂症患者中与额叶/执行功能障碍相关的行为很常见。我们的目的是再次证实精神分裂症患者的脑形态异常会与支持额叶系统行为的区域重叠，并检查精神分裂症患者脑结构异常与额叶行为缺陷之间是否存在任何特定关联。
26例精神分裂症患者和26例匹配的健康对照者接受了结构磁共振成像，并通过自评问卷“额叶系统行为量表（FrSBe）”评估了他们的额叶功能。我们应用基于体素的形态学测量（VBM）来研究脑区体积变化。
与健康对照者相比，精神分裂症患者在多个额叶和颞叶结构中灰质体积减少，即双侧背外侧前额叶皮质（DLPFC）、双侧内侧前额叶皮质、左侧腹外侧前额叶皮质、双侧前扣带回皮质和双侧颞上回。患者组中FrSBe执行功能障碍子量表的得分与双侧DLPFC的体积减少相关。
我们的结果表明，DLPFC的病变可能是精神分裂症患者现实生活中执行功能障碍行为的神经基础。
