Chanson J B, Kremer S, Blanc F, Marescaux C, Namer I J, de Seze J
Service de Neurologie, Hôpital Civil, 1 place de l'Hôpital, Strasbourg, France.
Mult Scler. 2009 Sep;15(9):1123-5. doi: 10.1177/1352458509106611. Epub 2009 Jul 22.
Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS).
We report a case of FAS as an initial symptom of a MS.
A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed.
Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS.
FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.
外国口音综合征（FAS）是一种不同于构音障碍或失语症的言语节律障碍。它在多发性硬化症（MS）中较为罕见。
我们报告一例以FAS为首发症状的MS病例。
一名右利手法国女性出现了孤立的德语外国口音。进行了脑磁共振成像（MRI）、单光子发射计算机断层扫描（SPECT）和脑脊液分析。
脑MRI显示左侧中央前回白质在T2加权图像上有大片高信号。单光子发射计算机断层扫描显示右侧中央前回灌注不足。脑脊液中寡克隆带不匹配以及后续MRI上新出现的异常高信号导致我们诊断为MS。
FAS可能是MS的首发症状。它可能是由于涉及右半球的广泛脑功能障碍所致。
