Mosam A, Carrara H, Shaik F, Uldrick T, Berkman A, Aboobaker J, Coovadia H M
Department of Dermatology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal.
Int J STD AIDS. 2009 Aug;20(8):553-6. doi: 10.1258/ijsa.2008.008372.
The aim of the study was to describe the temporal trends in the incidence of Kaposi's sarcoma (KS) in black South Africans in KwaZulu-Natal (KZN). The study was designed as a retrospective record review. The incidence of Kaposi's sarcoma was estimated using administrative records for patients receiving care for KS through public sector oncology clinics in KZN, 1983-2006. Annual age-standardized incidence rates were calculated using provincial census data for the denominator. Age-specific rates were calculated for the pre-AIDS (1983-1989) and for the generalized AIDS epidemic eras (2006). Age-standardized incidence of KS increased in KZN from <1:100,000 in 1990 to at least 15:100,000 in 2006; this increase was observed in both men and women. There was a shift in the peak age-specific incidence rates from the sixth decade of life in the pre-AIDS era to the fourth and fifth decades in the AIDS era. In conclusion, KS is a growing public health problem in KZN, South Africa. These data reinforce the need for comprehensive national access to and roll-out of antiretroviral drugs, given their success in prevention and treatment of KS in first-world settings.
该研究的目的是描述夸祖鲁 - 纳塔尔省（KZN）南非黑人中卡波西肉瘤（KS）发病率的时间趋势。该研究设计为回顾性记录审查。利用1983 - 2006年通过KZN公共部门肿瘤诊所接受KS治疗的患者的管理记录来估计卡波西肉瘤的发病率。使用省级人口普查数据作为分母计算年度年龄标准化发病率。计算了艾滋病流行前（1983 - 1989年）和广泛艾滋病流行时代（2006年）的年龄别发病率。KZN中KS的年龄标准化发病率从1990年的<1：100,000增加到2006年至少15：100,000；男性和女性均出现这种增加。年龄别发病率的峰值从艾滋病流行前时代的第六个十年转移到了艾滋病时代的第四和第五个十年。总之，KS在南非KZN是一个日益严重的公共卫生问题。鉴于抗逆转录病毒药物在第一世界环境中预防和治疗KS方面取得的成功，这些数据强化了全面普及和推广抗逆转录病毒药物的必要性。
