南非夸祖鲁 - 纳塔尔省抗逆转录病毒联合治疗方案对艾滋病相关卡波西肉瘤治疗早期效果的评估。

An evaluation of the early effects of a combination antiretroviral therapy programme on the management of AIDS-associated Kaposi's sarcoma in KwaZulu-Natal, South Africa.

作者信息

Mosam A, Uldrick T S, Shaik F, Carrara H, Aboobaker J, Coovadia H

机构信息

Department of Dermatology, Nelson R Mandela School of Medicine, CAPRISA, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Int J STD AIDS. 2011 Nov;22(11):671-3. doi: 10.1258/ijsa.2009.009145.

DOI:10.1258/ijsa.2009.009145

Abstract

Roll-out of combination antiretroviral therapy (cART) in South Africa should impact on AIDS-associated Kaposi's sarcoma (KS). Government provision began in 2003, with 23% coverage for World Health Organization (WHO) stage IV AIDS in 2006. To assess the effect of cART availability on KS management, we evaluated records from 701 KS patients seen at a tertiary oncology centre in KwaZulu-Natal, South Africa, from 1995 to 2006. Associations between cART use and measures of KS care were evaluated. cART availability was 0% prior to 2001, 9.6% (2001-2003) and 44% (2004-2006). Documentation of HIV status increased incrementally from 65% to 92%. cART was associated with chemotherapy administration: 56% on cART versus 17% not on cART (P < 0.001); and less loss to follow-up, 13% on cART versus 38% not on cART (P < 0.001). cART availability improves the care of AIDS-associated KS. Further increases in cART availability for this population are needed in South Africa.

摘要

在南非推行联合抗逆转录病毒疗法（cART）应会对与艾滋病相关的卡波西肉瘤（KS）产生影响。政府于2003年开始提供该疗法，2006年世界卫生组织（WHO）IV期艾滋病患者的覆盖率达到23%。为评估cART可及性对KS治疗的影响，我们评估了1995年至2006年期间在南非夸祖鲁 - 纳塔尔省一家三级肿瘤中心就诊的701例KS患者的记录。评估了cART使用与KS治疗措施之间的关联。2001年之前cART可及率为0%，2001 - 2003年为9.6%，2004 - 2006年为44%。HIV感染状况的记录从65%逐步增加到92%。cART与化疗给药相关：接受cART治疗的患者中56%接受了化疗，未接受cART治疗的患者中这一比例为17%（P < 0.001）；失访情况也较少，接受cART治疗的患者失访率为13%，未接受cART治疗的患者失访率为38%（P < 0.001）。cART的可及性改善了与艾滋病相关的KS的治疗。南非需要进一步提高该人群cART的可及率。