精神疾病的全基因组关联研究：该框架是否建立在坚实的基础之上？ - Suppr

Suppr

超能文献

GWAS for psychiatric disease: is the framework built on a solid foundation?

作者信息

Mitchell K J, Porteous D J

出版信息

Mol Psychiatry. 2009 Aug;14(8):740-1. doi: 10.1038/mp.2009.17.

DOI:10.1038/mp.2009.17

PMID:19626023

Abstract

摘要

相似文献

GWAS for psychiatric disease: is the framework built on a solid foundation?

Mol Psychiatry. 2009 Aug;14(8):740-1. doi: 10.1038/mp.2009.17.

An Overview of Genome-Wide Association Studies.

Methods Mol Biol. 2018;1754:97-108. doi: 10.1007/978-1-4939-7717-8_6.

A current snapshot of common genomic variants contribution in psychiatric disorders.

Am J Med Genet B Neuropsychiatr Genet. 2016 Dec;171(8):997-1005. doi: 10.1002/ajmg.b.32475. Epub 2016 Aug 3.

A new role for endophenotypes in the GWAS era: functional characterization of risk variants.

Harv Rev Psychiatry. 2010 Jan-Feb;18(1):67-74. doi: 10.3109/10673220903523532.

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

Nat Neurosci. 2015 Feb;18(2):199-209. doi: 10.1038/nn.3922. Epub 2015 Jan 19.

A framework for interpreting genome-wide association studies of psychiatric disorders.

Mol Psychiatry. 2009 Jan;14(1):10-7. doi: 10.1038/mp.2008.126. Epub 2008 Nov 11.

Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.

Am J Med Genet B Neuropsychiatr Genet. 2021 Jan;186(1):16-27. doi: 10.1002/ajmg.b.32834. Epub 2021 Feb 11.

Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint.

J Hum Genet. 2021 Jan;66(1):53-60. doi: 10.1038/s10038-020-0814-y. Epub 2020 Aug 7.

Power in GWAS: lifting the curse of the clinical cut-off.

Mol Psychiatry. 2013 Jan;18(1):2-3. doi: 10.1038/mp.2012.65. Epub 2012 May 22.

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies.

J Hum Genet. 2021 Jan;66(1):25-37. doi: 10.1038/s10038-020-00838-1. Epub 2020 Sep 21.

引用本文的文献

A rare variant in associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2404754122. doi: 10.1073/pnas.2404754122. Epub 2025 Apr 14.

Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families.

Open J Genet. 2013 Dec;3(4):243-252. doi: 10.4236/ojgen.2013.34027.

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function.

Front Neural Circuits. 2013 Apr 8;7:63. doi: 10.3389/fncir.2013.00063. eCollection 2013.

ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families.

Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):445-55. doi: 10.1002/ajmg.b.32048. Epub 2012 Apr 9.

The small world of psychopathology.

PLoS One. 2011;6(11):e27407. doi: 10.1371/journal.pone.0027407. Epub 2011 Nov 17.

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

Cell Mol Life Sci. 2012 Mar;69(6):857-96. doi: 10.1007/s00018-011-0844-x. Epub 2011 Oct 16.

DISC1-binding proteins in neural development, signalling and schizophrenia.

Neuropharmacology. 2012 Mar;62(3):1230-41. doi: 10.1016/j.neuropharm.2010.12.027. Epub 2010 Dec 31.

Response to Mitchell and Porteus.

Mol Psychiatry. 2010 May;15(5):450-2. doi: 10.1038/mp.2009.106.

The role of genetics in the etiology of schizophrenia.

Psychiatr Clin North Am. 2010 Mar;33(1):35-66. doi: 10.1016/j.psc.2009.12.003.

Genome-wide association studies: a primer.

Psychol Med. 2010 Jul;40(7):1063-77. doi: 10.1017/S0033291709991723. Epub 2009 Nov 9.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

相似文献

GWAS for psychiatric disease: is the framework built on a solid foundation?

Mol Psychiatry. 2009 Aug;14(8):740-1. doi: 10.1038/mp.2009.17.

An Overview of Genome-Wide Association Studies.

Methods Mol Biol. 2018;1754:97-108. doi: 10.1007/978-1-4939-7717-8_6.

A current snapshot of common genomic variants contribution in psychiatric disorders.

Am J Med Genet B Neuropsychiatr Genet. 2016 Dec;171(8):997-1005. doi: 10.1002/ajmg.b.32475. Epub 2016 Aug 3.

A new role for endophenotypes in the GWAS era: functional characterization of risk variants.

Harv Rev Psychiatry. 2010 Jan-Feb;18(1):67-74. doi: 10.3109/10673220903523532.

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.

Nat Neurosci. 2015 Feb;18(2):199-209. doi: 10.1038/nn.3922. Epub 2015 Jan 19.

A framework for interpreting genome-wide association studies of psychiatric disorders.

Mol Psychiatry. 2009 Jan;14(1):10-7. doi: 10.1038/mp.2008.126. Epub 2008 Nov 11.

Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel.

Am J Med Genet B Neuropsychiatr Genet. 2021 Jan;186(1):16-27. doi: 10.1002/ajmg.b.32834. Epub 2021 Feb 11.

Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint.

J Hum Genet. 2021 Jan;66(1):53-60. doi: 10.1038/s10038-020-0814-y. Epub 2020 Aug 7.

Power in GWAS: lifting the curse of the clinical cut-off.

Mol Psychiatry. 2013 Jan;18(1):2-3. doi: 10.1038/mp.2012.65. Epub 2012 May 22.

Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies.

J Hum Genet. 2021 Jan;66(1):25-37. doi: 10.1038/s10038-020-00838-1. Epub 2020 Sep 21.

引用本文的文献

A rare variant in associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.

Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2404754122. doi: 10.1073/pnas.2404754122. Epub 2025 Apr 14.

Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families.

Open J Genet. 2013 Dec;3(4):243-252. doi: 10.4236/ojgen.2013.34027.

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function.

Front Neural Circuits. 2013 Apr 8;7:63. doi: 10.3389/fncir.2013.00063. eCollection 2013.

ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families.

Am J Med Genet B Neuropsychiatr Genet. 2012 Jun;159B(4):445-55. doi: 10.1002/ajmg.b.32048. Epub 2012 Apr 9.

The small world of psychopathology.

PLoS One. 2011;6(11):e27407. doi: 10.1371/journal.pone.0027407. Epub 2011 Nov 17.

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

Cell Mol Life Sci. 2012 Mar;69(6):857-96. doi: 10.1007/s00018-011-0844-x. Epub 2011 Oct 16.

DISC1-binding proteins in neural development, signalling and schizophrenia.

Neuropharmacology. 2012 Mar;62(3):1230-41. doi: 10.1016/j.neuropharm.2010.12.027. Epub 2010 Dec 31.

Response to Mitchell and Porteus.

Mol Psychiatry. 2010 May;15(5):450-2. doi: 10.1038/mp.2009.106.

The role of genetics in the etiology of schizophrenia.

Psychiatr Clin North Am. 2010 Mar;33(1):35-66. doi: 10.1016/j.psc.2009.12.003.

Genome-wide association studies: a primer.

Psychol Med. 2010 Jul;40(7):1063-77. doi: 10.1017/S0033291709991723. Epub 2009 Nov 9.