Tadić André, Elsässer Amelie, Victor Anja, von Cube Robert, Başkaya Omür, Wagner Stefanie, Lieb Klaus, Höppner Wolfgang, Dahmen Norbert
Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany.
J Neural Transm (Vienna). 2009 Sep;116(9):1185-8. doi: 10.1007/s00702-009-0264-3. Epub 2009 Jul 21.
The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.
本研究的目的是检测边缘型人格障碍（BPD）与5-羟色胺受体1B（HTR1B）及脑源性神经营养因子（BDNF）基因变异之间的关联。我们对161例白种人BPD患者和156例健康对照者的4个HTR1B及功能性BDNF G196A标记进行了基因分型。两组在HTR1B标记的基因型或单倍型分布以及BDNF标记的基因型分布上均无显著差异。逻辑回归分析显示，携带HTR1B A-161等位基因的BPD患者中，BDNF 196A等位基因的比例过高。
