脑源性神经营养因子Val66Met多态性与人类皮质形态的变异
The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology.
作者信息
Pezawas Lukas, Verchinski Beth A, Mattay Venkata S, Callicott Joseph H, Kolachana Bhaskar S, Straub Richard E, Egan Michael F, Meyer-Lindenberg Andreas, Weinberger Daniel R
机构信息
Genes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1379, USA.
出版信息
J Neurosci. 2004 Nov 10;24(45):10099-102. doi: 10.1523/JNEUROSCI.2680-04.2004.
Abstract
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
摘要
脑源性神经营养因子基因（val66met）的变异会影响其在神经元中的功能，预示人类记忆的差异，并且与多种神经和精神疾病相关。在此，我们表明，在对大量正常个体进行的磁共振成像扫描中，这种多态性会影响海马体和前额叶皮质的解剖结构，从而确定了与学习和记忆相关的脑形态变异的遗传机制。
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