Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Adv Biochem Eng Biotechnol. 2010;122:235-57. doi: 10.1007/10_2008_17.
In recent years, with the booming economy, the Chinese government has increased its financial input to biotechnology research, which has led to remarkable achievements by China in modern biotechnology. As one of the key parts of modern biotechnology, industrial biotechnology will be crucial for China's sustainable development in this century. This review presents an overview of Chinese industrial biotechnology in last 10 years. Modern biotechnology had been classified into metabolic engineering and systems biology framework. Metabolic engineering is a field of broad fundamental and practical concept so we integrated the related technology achievements into the real practices of many metabolic engineering cases, such as biobased products production, environmental control and others. Now metabolic engineering is developing towards the systems level. Chinese researchers have also embraced this concept and have contributed invaluable things in genomics, transcriptomics, proteomics and related bioinformatics. A series of advanced laboratories or centers were established which will represent Chinese modern biotechnology development in the near future. At the end of this review, metabolic network research advances have also been mentioned.
近年来，随着经济的蓬勃发展，中国政府增加了对生物技术研究的财政投入，这使得中国在现代生物技术方面取得了显著的成就。作为现代生物技术的关键部分之一，工业生物技术将是中国本世纪可持续发展的关键。本文综述了过去 10 年中国工业生物技术的发展情况。现代生物技术已被归类为代谢工程和系统生物学框架。代谢工程是一个具有广泛基础和实用概念的领域，因此我们将相关技术成果整合到许多代谢工程案例的实际应用中，如生物基产品生产、环境控制等。现在代谢工程正在向系统水平发展。中国研究人员也接受了这一概念，并在基因组学、转录组学、蛋白质组学和相关生物信息学方面做出了宝贵的贡献。一系列先进的实验室或中心已经建立，它们将代表中国现代生物技术的发展方向。在本文的最后，还提到了代谢网络研究的进展。
