Suzuki Keishiro, Nishioka Takeshi, Homma Akihiro, Tsuchiya Kazuhiko, Yasuda Motoaki, Aoyama Hidefumi, Onimaru Rikiya, Tamaki Nagara, Shirato Hiroki
Department of Radiology, Hokkaido University Graduate School of Medicine, Nishi 7-chome Kita 15-Jo, Kita-ku, Sapporo 060-8638, Japan.
Jpn J Radiol. 2009 Jul;27(6):237-42. doi: 10.1007/s11604-009-0330-7. Epub 2009 Jul 22.
The aim of this study was to determine if the standardized uptake value (SUV) of fluorodeoxyglucose positron emission tomography (FDG-PET) for head and neck cancer can predict the outcome of radiotherapy and if the SUV is correlated with histological grade, mitosis, and apoptosis.
The study included 45 head and neck cancer patients who underwent FDG-PET scanning before radiotherapy. The maximum SUV (SUVmax) of their primary lesions were measured. Biopsy was performed in all patients to determine the histological diagnosis. Altogether, 14 biopsy specimens were available for mitotic and apoptotic cell counts.
The mean SUVmax of T3 tumors was significantly higher than that of T1 (P = 0.01) and T2 (P = 0.011) tumors. The mean SUVmax of stage II disease was significantly lower than that of stage III (P = 0.028) and stage IV (P = 0.007) disease. There was a tendency toward a better locoregional control rate and disease-free survival for the lower SUV group using a cutoff value of 5.5. For 41 patients with squamous cell carcinoma or undifferentiated carcinoma, SUVmax did not reflect the histological grade. There was no correlation between the SUVmax and the mitotic/apoptotic status.
SUVmax may correlate with the T classification and stage, but there was no predictive value for outcome of radiation therapy. Neither histological grading nor mitotic/apoptotic status is correlated with SUVmax.
本研究旨在确定头颈部癌氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）的标准化摄取值（SUV）是否能预测放疗结果，以及SUV是否与组织学分级、有丝分裂和细胞凋亡相关。
本研究纳入45名头颈部癌患者，这些患者在放疗前行FDG-PET扫描。测量其原发灶的最大SUV（SUVmax）。所有患者均进行活检以确定组织学诊断。总共14份活检标本可用于有丝分裂和凋亡细胞计数。
T3肿瘤的平均SUVmax显著高于T1（P = 0.01）和T2（P = 0.011）肿瘤。II期疾病的平均SUVmax显著低于III期（P = 0.028）和IV期（P = 0.007）疾病。使用截断值5.5时，较低SUV组的局部区域控制率和无病生存率有更好的趋势。对于41例鳞状细胞癌或未分化癌患者，SUVmax未反映组织学分级。SUVmax与有丝分裂/凋亡状态之间无相关性。
SUVmax可能与T分类和分期相关，但对放疗结果无预测价值。组织学分级和有丝分裂/凋亡状态均与SUVmax无关。
