Kim Donghyun, Kim Wontaek, Lee Joohye, Ki Yongkan, Lee Byungjoo, Cho Kyusup, Kim Seongjang, Nam Jiho, Lee Jinchoon, Kim Dongwon
Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
Department of Otorhinolaryngology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Pusan National University, Busan, Korea.
Head Neck. 2016 May;38(5):755-61. doi: 10.1002/hed.23953. Epub 2015 May 26.
The purpose of this study was to determine whether the maximum standardized uptake value (SUVmax) of the primary tumor on pretreatment (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) has prognostic significance in patients with adenoid cystic carcinoma (ACC) of the head and neck.
A retrospective review was carried out on 34 patients with ACC of the head and neck who underwent pretreatment (18)F-FDG PET imaging from June 2005 through July 2009. All patients underwent surgery with curative intent, and 26 of them received adjuvant radiotherapy (RT).
When subjects were stratified into 2 groups according to a cutoff value for SUVmax of 4.15, the risk of distant metastasis was significantly high in patients with high SUVmax (p = .014). Multivariate analysis showed that high SUVmax and histologic grade 3 were independent poor prognostic factors for distant metastasis-free and disease-free survival.
Pretreatment SUVmax of the primary tumor is an independent prognostic factor in patients with ACC of the head and neck.
本研究旨在确定治疗前（18）F - 氟脱氧葡萄糖正电子发射断层扫描（（18）F - FDG PET）上原发肿瘤的最大标准化摄取值（SUVmax）对头颈部腺样囊性癌（ACC）患者是否具有预后意义。
对2005年6月至2009年7月期间接受治疗前（18）F - FDG PET成像的34例头颈部ACC患者进行回顾性研究。所有患者均接受了根治性手术，其中26例接受了辅助放疗（RT）。
当根据SUVmax的临界值4.15将受试者分为两组时，SUVmax高的患者远处转移风险显著更高（p = 0.014）。多变量分析显示，高SUVmax和组织学3级是无远处转移生存和无病生存的独立不良预后因素。
原发肿瘤的治疗前SUVmax是头颈部ACC患者的独立预后因素。
