预测肌酐清除率以评估人类慢性肾病中的肾小球滤过率。

Predicted creatinine clearance to assess glomerular filtration rate in chronic renal disease in humans.

作者信息

DeSanto N G, Coppola S, Anastasio P, Coscarella G, Capasso G, Bellini L, Santangelo R, Massimo L, Siciliano A

机构信息

1st Faculty of Medicine, Università Federico II, Naples, Italy.

出版信息

Am J Nephrol. 1991;11(3):181-5. doi: 10.1159/000168300.

DOI:10.1159/000168300

PMID:1962664

Abstract

The work was designed to assess the suitability of both measured endogenous creatinine clearance (CCR) and predicted creatinine clearance (P-CCR) to evaluate GFR in chronic renal disease (CRD) by utilizing the renal clearance of inulin (CIN) as gold standard. A total of 124 subjects were studied (62 healthy, 62 with CRF). CCR significantly overestimated GFR in healthy subjects as well as in CRF, whereas P-CCR was identical to GFR. The CCR/CIN ratio which calculates the fractional creatinine clearance and provides a rough estimation of the contribution of creatinine secretion in explaining the differences between CCR and GFR was increased in CRD and especially in CRD of glomerular origin. The ration P-CCR/CIN was significantly lower than CCR/CIN in healthy subjects and in patients with CRD of glomerular origin. The data are against the use of CCR in assessing GFR in healthy subjects and in patients with CRD.

摘要

该研究旨在通过将菊粉肾清除率（CIN）作为金标准，评估实测内生肌酐清除率（CCR）和预测肌酐清除率（P-CCR）在评估慢性肾病（CRD）患者肾小球滤过率（GFR）方面的适用性。共研究了124名受试者（62名健康者，62名慢性肾衰竭患者）。CCR在健康受试者和慢性肾衰竭患者中均显著高估了GFR，而P-CCR与GFR相同。计算肌酐清除分数并粗略估计肌酐分泌在解释CCR和GFR差异中作用的CCR/CIN比值，在慢性肾病患者中升高，尤其是在肾小球源性慢性肾病患者中。在健康受试者和肾小球源性慢性肾病患者中，P-CCR/CIN比值显著低于CCR/CIN。这些数据不支持在健康受试者和慢性肾病患者中使用CCR评估GFR。