Faivre Vincent, Bardonnet Pierre-Louis, Boullanger Paul, Amenitsch Heinz, Ollivon Michel, Falson Françoise
Laboratoire de Physico-Chimie des Systèmes Polyphasés, UMR CNRS 8612-IFR 141, Université Paris-Sud, 5 rue J.B. Clement, 92296 Châtenay-Malabry, France.
Langmuir. 2009 Aug 18;25(16):9424-31. doi: 10.1021/la900492j.
Lectin-sugar recognition systems are of interest in the pharmaceutical field, especially for the development of drug carriers, tailored for selective delivery. This paper deals with the anhydrous and aqueous self-organization properties of a synthetic cholesteryl oligoethyleneglycol glycoside with the aim of their incorporation in liposomes. Successive phases (lamellar, R3m, Im3m, micelles) have been described depending on water content and temperature. As a result of the presence of sugar residues and their hydration ability, this glycolipid shows a large range of packing parameter with increasing water content. However, because of oligoethyleneglycol spacer, a slight dehydration has been observed with increasing temperature from 20 to 60 degrees C.
凝集素-糖识别系统在制药领域备受关注，特别是在开发用于选择性递送的药物载体方面。本文研究了一种合成胆固醇寡聚乙二醇糖苷的无水和水相自组装性质，目的是将其掺入脂质体中。根据水含量和温度的不同，描述了连续的相（层状相、R3m相、Im3m相、胶束相）。由于糖残基的存在及其水合能力，随着水含量的增加，这种糖脂表现出广泛的堆积参数范围。然而，由于存在寡聚乙二醇间隔基，从20℃到60℃温度升高时观察到了轻微的脱水现象。
