一种外周血管扩张剂-β-肾上腺素能阻滞剂的应用方法。
An approach to peripheral vasodilator-beta-adrenergic blocking agents.
作者信息
Baldwin J J, Hirschmann R, Lumma P K, Lumma W C, Ponticello G S, Sweet C S, Scriabine A
出版信息
J Med Chem. 1977 Aug;20(8):1024-9. doi: 10.1021/jm00218a007.
PMID:19628
Abstract
The syntheses of 2-phenyl- and 2-pyridyl-4-trifluoromethylimidazoles having a 3-tert-butylamino-2-hydroxypropoxy moiety attached to the aryl or heteroaryl substituent are described. Structure--activity relationships based on results from an evaluation of these compounds for antihypertensive, vasodilating, and beta-adrenergic blocking activities are discussed.
摘要
描述了连接有3-叔丁基氨基-2-羟基丙氧基部分至芳基或杂芳基取代基的2-苯基-和2-吡啶基-4-三氟甲基咪唑的合成方法。基于对这些化合物的抗高血压、血管舒张和β-肾上腺素能阻断活性评估结果的构效关系也进行了讨论。
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