Pernot F, Schleiffer R, Vincent M, Sassard J, Gairard A
CNRS UA 600, Université Louis Pasteur, Strasbourg, France.
J Hypertens. 1990 Dec;8(12):1111-7. doi: 10.1097/00004872-199012000-00007.
We have studied the effect of parathyroidectomy on the systolic blood pressure, cardiovascular reactivity and the contractile response of isolated aorta to norepinephrine in the genetically hypertensive Lyon rat strain (LH), parathyroidectomized hypertensive Lyon rats (LH-PTX) and parathyroidectomized hypertensive Lyon rats given a Ca-enriched diet to re-establish normocalcemia (LH-PTX + Ca). Parathyroidectomy significantly lessened (-20%) the development of elevated blood pressure. In the LH-PTX + Ca, the blood pressure was lower than that of LH controls but was higher than that of LH-PTX. At 23 weeks, in vivo responsiveness to norepinephrine and angiotensin II was significantly lower in the LH-PTX and only slightly decreased in the LH-PTX + Ca. In contrast, at the same age, the in vitro contractile response of isolated aortas to norepinephrine was significantly higher in the LH-PTX compared with other groups. Interestingly, without endothelium, this difference disappeared. In conclusion, parathyroidectomy lessened the blood pressure elevation in the Lyon model of hypertensive rats via mechanisms that are partly independent of serum calcium levels.
我们研究了甲状旁腺切除术对遗传性高血压里昂大鼠品系（LH）、甲状旁腺切除的高血压里昂大鼠（LH-PTX）以及给予高钙饮食以恢复正常血钙水平的甲状旁腺切除的高血压里昂大鼠（LH-PTX + Ca）的收缩压、心血管反应性和离体主动脉对去甲肾上腺素的收缩反应的影响。甲状旁腺切除术显著减轻了（-20%）血压升高的发展。在LH-PTX + Ca组中，血压低于LH对照组，但高于LH-PTX组。在23周时，LH-PTX组对去甲肾上腺素和血管紧张素II的体内反应性显著降低，而LH-PTX + Ca组仅略有下降。相反，在同一年龄，LH-PTX组离体主动脉对去甲肾上腺素的体外收缩反应显著高于其他组。有趣的是，去除内皮后，这种差异消失。总之，甲状旁腺切除术通过部分独立于血清钙水平的机制减轻了高血压大鼠里昂模型中的血压升高。
