甲状旁腺切除术对自发性高血压大鼠高血压发展及心房反应性的影响。

Effect of parathyroidectomy on development of hypertension and atrial responsiveness in spontaneous hypertensive rats.

Schleiffer R, Ghysel-Burton J, Finet M, Gairard A

Pharmacologie Cellulaire et Moléculaire, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, Illkirch, France.

Clin Exp Pharmacol Physiol. 1991 Mar;18(3):145-54. doi: 10.1111/j.1440-1681.1991.tb01425.x.

Abstract

In order to further clarify the relationships between parathyroid function and development of hypertension, the effects of parathyroidectomy (PTX) on blood pressure and on responsiveness of atria isolated from spontaneous hypertensive rats (SHR) were examined. 2. PTX was carried out in 6-week-old SHR and normotensive Wistar rats. The experiments were performed 2 weeks after surgery. 3. PTX reduced the plasma calcium concentration and decreased atrial calcium content in SHR. On the other hand, basal contractile force and beat frequency of isolated atria were higher in PTX SHR than in sham-operated SHR. In response to cumulative addition of isoprenaline, atria from PTX SHR displayed diminished inotropic and chronotropic responses compared with sham-operated SHR. Similar results were obtained in atria isolated from Wistar rats. When calcium sensitivity was studied in atria from Wistar rats, basal and isoprenaline-induced maximum contractile forces were higher in PTX group than in the sham-operated group. Nevertheless, basal and isoprenaline-induced maximum contractile forces, determined at the respective plasma ionized calcium concentration of PTX and sham-operated groups (0.83 and 1.22 mmol/L), were not significantly different. 4. Our results do not favour a role for alteration in atrial activity as a causal mechanism in delayed development of experimental genetic hypertension after parathyroidectomy.

摘要

为了进一步阐明甲状旁腺功能与高血压发展之间的关系，研究了甲状旁腺切除术（PTX）对自发性高血压大鼠（SHR）血压及离体心房反应性的影响。2. 对6周龄的SHR和正常血压的Wistar大鼠进行甲状旁腺切除术。实验在术后2周进行。3. PTX降低了SHR的血浆钙浓度并减少了心房钙含量。另一方面，PTX处理的SHR离体心房的基础收缩力和搏动频率高于假手术的SHR。与假手术的SHR相比，PTX处理的SHR心房对异丙肾上腺素累积添加的反应中，变力性和变时性反应减弱。从Wistar大鼠分离的心房也得到了类似结果。在研究Wistar大鼠心房的钙敏感性时，PTX组的基础和异丙肾上腺素诱导的最大收缩力高于假手术组。然而，在PTX组和假手术组各自的血浆离子钙浓度（0.83和1.22 mmol/L）下测定的基础和异丙肾上腺素诱导的最大收缩力并无显著差异。4. 我们的结果不支持心房活动改变作为甲状旁腺切除术后实验性遗传性高血压延迟发展的因果机制。