苯并[c][2,7]萘啶作为丙酮酸脱氢酶激酶-1（PDK-1）的抑制剂
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
作者信息
Kim Kyung-Hee, Wissner Allan, Floyd Middleton B, Fraser Heidi L, Wang Yanong D, Dushin Russell G, Hu Yongbo, Olland Andrea, Guo Bing, Arndt Kim
机构信息
Wyeth Research, Chemical Sciences, 401 N. Middletown Road, Pearl River, NY 10965, USA.
出版信息
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5225-8. doi: 10.1016/j.bmcl.2009.07.007. Epub 2009 Jul 8.
PMID:19628388
Abstract
A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a complex with PDK-1.
摘要
制备了一系列取代苯并[c][2,7]萘啶，并显示出对PDK-1具有良好的抑制活性。介绍了该系列化合物的合成方法、构效关系以及其中一个类似物与PDK-1复合物的X射线晶体结构。
Zotero 插件