上皮细胞作为免疫效应细胞：CD40的作用
Epithelial cells as immune effector cells: the role of CD40.
作者信息
Dugger Kari, Lowder Thomas W, Tucker Torry A, Schwiebert Lisa M
机构信息
Department of Physiology and Biophysics, University of Alabama at Birmingham, AL 35294-0005, USA.
出版信息
Semin Immunol. 2009 Oct;21(5):289-92. doi: 10.1016/j.smim.2009.06.002. Epub 2009 Jul 22.
Abstract
Through the expression of inflammatory mediators and immune-related molecules, epithelial cells function as immune effector cells in a wide variety of tissues; the expression of the CD40 receptor on these cells contributes this role. Engagement of CD40 activates epithelial cells and results in their release of pro- and anti-inflammatory mediators as well as pro-fibrotic molecules. As such, epithelial CD40 has been implicated in the pathogenesis of inflammatory disorders, generation of self-tolerance, and rejection of allografts.
摘要
通过炎症介质和免疫相关分子的表达，上皮细胞在多种组织中作为免疫效应细胞发挥作用；这些细胞上CD40受体的表达促成了这一作用。CD40的激活会使上皮细胞活化，并导致其释放促炎和抗炎介质以及促纤维化分子。因此，上皮细胞CD40与炎症性疾病的发病机制、自身耐受性的产生以及同种异体移植物的排斥反应有关。
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本文引用的文献
1
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Proc Am Thorac Soc. 2009 May 1;6(3):249-55. doi: 10.1513/pats.200806-054RM.
2
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.肿瘤坏死因子家族受体RANK和CD40协同建立胸腺髓质微环境和自身耐受性。
Immunity. 2008 Sep 19;29(3):423-37. doi: 10.1016/j.immuni.2008.06.015.
3
Thymic stromal lymphopoietin: a new cytokine in asthma.胸腺基质淋巴细胞生成素：哮喘中的一种新型细胞因子。
Curr Opin Pharmacol. 2008 Jun;8(3):249-54. doi: 10.1016/j.coph.2008.03.002. Epub 2008 Apr 29.
4
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7
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