Freedman R R, Embury J, Migály P, Keegan D, Pandey G N, Javaid J I, Davis J M
Lafayette Clinic, Detroit, MI 48207.
Psychosom Med. 1990 Nov-Dec;52(6):624-30. doi: 10.1097/00006842-199011000-00004.
Although agonist-induced desensitization of adrenergic receptors has been previously demonstrated, the regulation of adrenergic receptors during acute psychological stress has not been investigated in humans. We studied 30 first year medical students during final examination week and one month earlier. Platelet alpha 2 receptor binding was measured using 3H-yohimbine and leukocyte beta 2 receptor binding was measured with 125I-CYP (Iodocyanopindolol). During final examination week, platelet alpha 2-receptor binding affinity was significantly reduced, while levels of plasma catecholamines and reported anxiety were significantly increased, compared with the earlier period. Students showing the greatest increases in plasma norepinephrine and in reported anxiety also demonstrated the greatest reductions in alpha 2 receptor binding affinity. These data show that acute psychological stress can produce adrenergic receptor desensitization, possibly through increased levels of circulating norepinephrine.
尽管先前已证实激动剂诱导的肾上腺素能受体脱敏现象，但急性心理应激期间肾上腺素能受体的调节在人类中尚未得到研究。我们对30名一年级医学生在期末考试周及一个月前进行了研究。使用3H-育亨宾测量血小板α2受体结合，用125I-CYP（碘氰吲哚洛尔）测量白细胞β2受体结合。与早期相比，在期末考试周期间，血小板α2受体结合亲和力显著降低，而血浆儿茶酚胺水平和报告的焦虑程度显著增加。血浆去甲肾上腺素和报告的焦虑增加最多的学生，其α2受体结合亲和力降低也最大。这些数据表明，急性心理应激可能通过循环中去甲肾上腺素水平的升高导致肾上腺素能受体脱敏。
