Department of Physical Education and Human Performance, Central Connecticut State University, New Britain, CT 06050, USA.
Gene. 2012 Nov 15;510(1):66-70. doi: 10.1016/j.gene.2012.08.020. Epub 2012 Sep 5.
We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program.
European-derived American volunteers (men=111, women=131, 23.4 ± 5.4 yr, 24.4 ± 4.6 kg·m(-2)) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A>G (rs1137100), 668 A>G (rs1137101), 3057 G>A (rs1805096), and 1968 G>C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12 wk of supervised RT with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates.
Adults with the LEP 19 GG genotype reported more kcal/wk in vigorous intensity PA (1273.3 ± 176.8, p=0.017) and sports/recreation (1922.8 ± 226.0, p<0.04) than A allele carriers (718.0 ± 147.2, 1328.6 ± 188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7 ± 1.6) than A allele carriers (35.0 ± 1.4, p=0.03). In response to RT, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05 ± 3186.7 vs. 52,321.87 ± 5125.05 mm(3), p=0.01) and subcutaneous fat volume (10,599.89 ± 3683.57 vs. -5224.73 ± 5923.98 mm(3), p=0.02) than adults with the LEPR 668 AA genotype, respectively.
LEP19 G>A and LEPR 668 A>G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed.
我们研究了瘦素（LEP）和瘦素受体（LEPR）单核苷酸多态性（SNP）对习惯性体力活动（PA）和身体成分对单侧上肢抗阻训练（RT）的反应的影响。
对欧洲裔美国志愿者（男性 111 名，女性 131 名，23.4±5.4 岁，24.4±4.6 kg·m(-2))进行 LEPR 19 G>A(rs2167270)和 LEPR 326 A>G(rs1137100)、668 A>G(rs1137101)、3057 G>A(rs1805096)和 1968 G>C(rs8179183)的基因分型。他们完成了 Paffenbarger 体力活动问卷。用 MRI 测量 12 周监督 RT 前后手臂肌肉和皮下脂肪体积。多元和重复测量方差分析测试了基因型和性别之间表型的差异，年龄和体重指数为协变量。
LEP 19 GG 基因型的成年人报告说，在剧烈强度 PA（1273.3±176.8，p=0.017）和运动/娱乐（1922.8±226.0，p<0.04）方面，每周消耗的卡路里多于 A 等位基因携带者（分别为 718.0±147.2 和 1328.6±188.2）。与 A 等位基因携带者相比（分别为 35.0±1.4 和 39.7±1.6），LEP 19 GG 基因型的成年人每周进行轻度 PA 的时间更长（p=0.03）。对 RT 的反应，LEPR 668 G 等位基因的成年人上肢肌肉体积增加（67,687.05±3186.7 与 52,321.87±5125.05 mm(3)，p=0.01）和皮下脂肪体积（10,599.89±3683.57 与-5224.73±5923.98 mm(3)，p=0.02）比 LEPR 668 AA 基因型的成年人更多。
LEP19 G>A 和 LEPR 668 A>G 与习惯性 PA 和 RT 对身体成分的反应相关。这些 LEP 和 LEPR SNPs 位于编码外显子中，可能影响 LEP 和 LEPR 的功能。需要进一步的研究来证实我们的发现，并确定我们观察到的 LEP 和 LEPR 基因型与 PA 和身体成分之间的关联机制。
