Dipartimento di Medicina Interna, Malattie Cardiovascolari e Nefrourologiche, Cattedra di Medicina Interna, European Society of Hypertension Excellence Centre, Università di Palermo, Palermo, Italy.
Am J Hypertens. 2009 Oct;22(10):1041-7. doi: 10.1038/ajh.2009.132. Epub 2009 Jul 23.
It has not been fully elucidated whether microalbuminuria (MAU) and high-sensitivity C-reactive protein (hsCRP) are associated with aortic distensibility independently of each other. Our study was aimed to evaluate the independent relationships of urinary albumin excretion rate (AER) and hsCRP with aortic stiffness in hypertensive patients.
We enrolled 140 untreated nondiabetic essential hypertensives (mean age: 48 +/- 12 years). In all subjects, 24-hour AER and plasma levels of hsCRP were determined by immunoenzymatic assay. MAU was defined as an AER of 20-200 microg/min. Aortic stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV).
Carotid-femoral PWV, adjusted for age and mean arterial pressure (MAP), was higher in subjects with MAU (n = 41) than in those without it (n = 99) (11.6 +/- 2.3 vs. 9.9 +/- 1.8 m/s; P < 0.001) and in subjects with hsCRP above the median value when compared to those with lower levels of hsCRP (10.8 +/- 2.1 vs. 10 +/- 2.1 m/s; P = 0.026). In multiple regression analysis, AER and hsCPR remained independent predictors of aortic stiffness (beta = 0.24; P < 0.001 and beta = 0.15; P = 0.03, respectively).
Our results suggest that in patients with essential hypertension, MAU and CRP are independently associated with an increased aortic stiffness.
微量白蛋白尿（MAU）和高敏 C 反应蛋白（hsCRP）是否与主动脉顺应性相互独立有关尚未完全阐明。我们的研究旨在评估尿白蛋白排泄率（AER）和 hsCRP 与高血压患者主动脉僵硬的独立关系。
我们纳入了 140 名未经治疗的非糖尿病原发性高血压患者（平均年龄：48 +/- 12 岁）。所有患者均通过免疫酶联测定法测定 24 小时 AER 和 hsCRP 血浆水平。MAU 定义为 AER 为 20-200μg/min。通过测量颈动脉-股动脉脉搏波速度（PWV）来评估主动脉僵硬。
校正年龄和平均动脉压（MAP）后，MAU 患者（n=41）的颈动脉-股动脉 PWV 高于无 MAU 患者（n=99）（11.6 +/- 2.3 比 9.9 +/- 1.8 m/s；P < 0.001），hsCRP 高于中位数的患者的颈动脉-股动脉 PWV 高于 hsCRP 较低的患者（10.8 +/- 2.1 比 10 +/- 2.1 m/s；P=0.026）。多元回归分析显示，AER 和 hsCRP 仍然是主动脉僵硬的独立预测因子（β=0.24；P<0.001 和 β=0.15；P=0.03）。
我们的结果表明，在原发性高血压患者中，MAU 和 CRP 与主动脉僵硬的增加独立相关。
